World Allergy Organization Journal (Jan 2016)
Biomarkers of the involvement of mast cells, basophils and eosinophils in asthma and allergic diseases
- Dean D. Metcalfe,
- Ruby Pawankar,
- Steven J. Ackerman,
- Cem Akin,
- Frederic Clayton,
- Franco H. Falcone,
- Gerald J. Gleich,
- Anne-Marie Irani,
- Mats W. Johansson,
- Amy D. Klion,
- Kristin M. Leiferman,
- Francesca Levi-Schaffer,
- Gunnar Nilsson,
- Yoshimichi Okayama,
- Calman Prussin,
- John T. Schroeder,
- Lawrence B. Schwartz,
- Hans-Uwe Simon,
- Andrew F. Walls,
- Massimo Triggiani
Affiliations
- Dean D. Metcalfe
- Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA; Correspondence:
- Ruby Pawankar
- Division of Allergy, Department of Pediatrics, Nippon Medical School, Tokyo, Japan
- Steven J. Ackerman
- Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois, Chicago, IL, USA
- Cem Akin
- Harvard Medical School, Brigham and Women’s Hospital, Boston, MA, USA
- Frederic Clayton
- Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, UT, USA
- Franco H. Falcone
- The School of Pharmacy, University of Nottingham, Nottingham, United Kingdom
- Gerald J. Gleich
- Department of Dermatology, University of Utah, School of Medicine, Salt Lake City, UT, USA
- Anne-Marie Irani
- Virginia Commonwealth University, Children’s Hospital of Richmond, Richmond, VA, USA
- Mats W. Johansson
- Department of Biomolecular Chemistry, University of Wisconsin, Madison, WI, USA
- Amy D. Klion
- Human Eosinophil Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
- Kristin M. Leiferman
- University of Utah, Salt Lake City, UT, USA
- Francesca Levi-Schaffer
- The Hebrew University of Jerusalem, Jerusalem, Israel
- Gunnar Nilsson
- Clinical Immunology and Allergy, Department of Medicine, Karolinska Institute and Karolinska University Hospital, Stockholm, Sweden
- Yoshimichi Okayama
- Allergy and Immunology Group, Research Institute of Medical Science, Nihon University Graduate School of Medicine, Tokyo, Japan
- Calman Prussin
- Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA
- John T. Schroeder
- Division of Allergy and Clinical Immunology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
- Lawrence B. Schwartz
- Virginia Commonwealth University, Richmond, VA, USA
- Hans-Uwe Simon
- University of Bern, Institute of Pharmacology, Bern, Switzerland
- Andrew F. Walls
- Southampton General Hospital, Immunopharmacology Group, Southampton, Hampshire, UK
- Massimo Triggiani
- Division of Allergy and Clinical Immunology, University of Salerno, Salerno, Italy
- Journal volume & issue
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Vol. 9
Abstract
Biomarkers of disease activity have come into wide use in the study of mechanisms of human disease and in clinical medicine to both diagnose and predict disease course; as well as to monitor response to therapeutic intervention. Here we review biomarkers of the involvement of mast cells, basophils, and eosinophils in human allergic inflammation. Included are surface markers of cell activation as well as specific products of these inflammatory cells that implicate specific cell types in the inflammatory process and are of possible value in clinical research as well as within decisions made in the practice of allergy-immunology.
