Nature Communications (Feb 2020)
Increased circulating levels of Factor H-Related Protein 4 are strongly associated with age-related macular degeneration
- Valentina Cipriani,
- Laura Lorés-Motta,
- Fan He,
- Dina Fathalla,
- Viranga Tilakaratna,
- Selina McHarg,
- Nadhim Bayatti,
- İlhan E. Acar,
- Carel B. Hoyng,
- Sascha Fauser,
- Anthony T. Moore,
- John R. W. Yates,
- Eiko K. de Jong,
- B. Paul Morgan,
- Anneke I. den Hollander,
- Paul N. Bishop,
- Simon J. Clark
Affiliations
- Valentina Cipriani
- William Harvey Research Institute, Clinical Pharmacology, Queen Mary University of London
- Laura Lorés-Motta
- Department of Ophthalmology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center
- Fan He
- Division of Evolution and Genomic Sciences, Faculty of Biology Medicine and Health, School of Biological Sciences, University of Manchester
- Dina Fathalla
- Systems Immunity URI, Division of Infection and Immunity, and UK DRI Cardiff, School of Medicine, Cardiff University
- Viranga Tilakaratna
- Division of Evolution and Genomic Sciences, Faculty of Biology Medicine and Health, School of Biological Sciences, University of Manchester
- Selina McHarg
- Division of Evolution and Genomic Sciences, Faculty of Biology Medicine and Health, School of Biological Sciences, University of Manchester
- Nadhim Bayatti
- Division of Evolution and Genomic Sciences, Faculty of Biology Medicine and Health, School of Biological Sciences, University of Manchester
- İlhan E. Acar
- Department of Ophthalmology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center
- Carel B. Hoyng
- Department of Ophthalmology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center
- Sascha Fauser
- Department of Ophthalmology, University Hospital of Cologne
- Anthony T. Moore
- UCL Institute of Ophthalmology, University College London
- John R. W. Yates
- UCL Institute of Ophthalmology, University College London
- Eiko K. de Jong
- Department of Ophthalmology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center
- B. Paul Morgan
- Systems Immunity URI, Division of Infection and Immunity, and UK DRI Cardiff, School of Medicine, Cardiff University
- Anneke I. den Hollander
- Department of Ophthalmology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center
- Paul N. Bishop
- Division of Evolution and Genomic Sciences, Faculty of Biology Medicine and Health, School of Biological Sciences, University of Manchester
- Simon J. Clark
- Division of Evolution and Genomic Sciences, Faculty of Biology Medicine and Health, School of Biological Sciences, University of Manchester
- DOI
- https://doi.org/10.1038/s41467-020-14499-3
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 15
Abstract
A locus on chromosome 1 encompassing the CFHR genes is highly associated with AMD risk. Here, Cipriani and colleagues investigate the role of CFHR4, encoding FHR-4, and demonstrate a relationship between AMD risk, circulating FHR-4 levels and genetic variants at this locus.
