Nature Communications (May 2018)
A comprehensive model for assessment of liver stage therapies targeting Plasmodium vivax and Plasmodium falciparum
- Alison Roth,
- Steven P. Maher,
- Amy J. Conway,
- Ratawan Ubalee,
- Victor Chaumeau,
- Chiara Andolina,
- Stephen A. Kaba,
- Amélie Vantaux,
- Malina A. Bakowski,
- Richard Thomson-Luque,
- Swamy Rakesh Adapa,
- Naresh Singh,
- Samantha J. Barnes,
- Caitlin A. Cooper,
- Mélanie Rouillier,
- Case W. McNamara,
- Sebastian A. Mikolajczak,
- Noah Sather,
- Benoît Witkowski,
- Brice Campo,
- Stefan H. I. Kappe,
- David E. Lanar,
- François Nosten,
- Silas Davidson,
- Rays H. Y. Jiang,
- Dennis E. Kyle,
- John H. Adams
Affiliations
- Alison Roth
- Department of Global Health, College of Public Health, Center for Global Health and Infectious Diseases Research, University of South Florida
- Steven P. Maher
- Department of Global Health, College of Public Health, Center for Global Health and Infectious Diseases Research, University of South Florida
- Amy J. Conway
- Department of Global Health, College of Public Health, Center for Global Health and Infectious Diseases Research, University of South Florida
- Ratawan Ubalee
- Department of Entomology, Armed Forces Research Institute of Medical Sciences (AFRIMS)
- Victor Chaumeau
- Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford
- Chiara Andolina
- Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford
- Stephen A. Kaba
- Malaria Vaccine Branch, Walter Reed Army Institute of Research
- Amélie Vantaux
- Malaria Molecular Epidemiology Unit, Institut Pasteur du Cambodge
- Malina A. Bakowski
- California Institute for Biomedical Research (Calibr)
- Richard Thomson-Luque
- Department of Global Health, College of Public Health, Center for Global Health and Infectious Diseases Research, University of South Florida
- Swamy Rakesh Adapa
- Department of Global Health, College of Public Health, Center for Global Health and Infectious Diseases Research, University of South Florida
- Naresh Singh
- Department of Global Health, College of Public Health, Center for Global Health and Infectious Diseases Research, University of South Florida
- Samantha J. Barnes
- Department of Global Health, College of Public Health, Center for Global Health and Infectious Diseases Research, University of South Florida
- Caitlin A. Cooper
- Center for Tropical and Emerging Global Diseases, University of Georgia
- Mélanie Rouillier
- Medicines for Malaria Venture
- Case W. McNamara
- California Institute for Biomedical Research (Calibr)
- Sebastian A. Mikolajczak
- Center for Infectious Disease Research
- Noah Sather
- Center for Infectious Disease Research
- Benoît Witkowski
- California Institute for Biomedical Research (Calibr)
- Brice Campo
- Medicines for Malaria Venture
- Stefan H. I. Kappe
- Center for Infectious Disease Research
- David E. Lanar
- Malaria Vaccine Branch, Walter Reed Army Institute of Research
- François Nosten
- Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford
- Silas Davidson
- Department of Entomology, Armed Forces Research Institute of Medical Sciences (AFRIMS)
- Rays H. Y. Jiang
- Department of Global Health, College of Public Health, Center for Global Health and Infectious Diseases Research, University of South Florida
- Dennis E. Kyle
- Department of Global Health, College of Public Health, Center for Global Health and Infectious Diseases Research, University of South Florida
- John H. Adams
- Department of Global Health, College of Public Health, Center for Global Health and Infectious Diseases Research, University of South Florida
- DOI
- https://doi.org/10.1038/s41467-018-04221-9
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 16
Abstract
Currently available platforms to study liver stage of Plasmodium species have limitations. Here, the authors show that primary human hepatocyte cultures in 384-well format support hypnozoite and other liver stage development and are suitable for drug and antibody screens.
