The Role of Stearoyl-coenzyme A Desaturase 1 in Liver Development, Function, and Pathogenesis

Fatemeh Mohammadzadeh; Vahid Hosseini; Alireza Alihemmati; Amir Mehdizadeh; Maghsod Shaaker; Gholamali Mosayyebi; Masoud Darabi

doi:10.15586/jrenhep.2019.49

Journal of Renal and Hepatic Disorders (Feb 2019)

The Role of Stearoyl-coenzyme A Desaturase 1 in Liver Development, Function, and Pathogenesis

Fatemeh Mohammadzadeh,
Vahid Hosseini,
Alireza Alihemmati,
Amir Mehdizadeh,
Maghsod Shaaker,
Gholamali Mosayyebi,
Masoud Darabi

Affiliations

Fatemeh Mohammadzadeh: Emergency Medicine Research Center Team, Department of Emergency Medicine, Tabriz University of Medical Sciences, 5166614756 Tabriz, Iran.
Vahid Hosseini: Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, 5166614756 Tabriz, Iran.
Alireza Alihemmati: Department of Anatomical Sciences, Faculty of Medicine, Tabriz University of Medical Sciences, 5166614756 Tabriz, Iran.
Amir Mehdizadeh: Emergency Medicine Research Center Team, Department of Emergency Medicine, Tabriz University of Medical Sciences, 5166614756 Tabriz, Iran.
Maghsod Shaaker: Emergency Medicine Research Center Team, Department of Emergency Medicine, Tabriz University of Medical Sciences, 5166614756 Tabriz, Iran.
Gholamali Mosayyebi: Liver and Gastrointestinal Research Center, Tabriz University of Medical Sciences, 5166614756 Tabriz, Iran.
Masoud Darabi: Emergency Medicine Research Center Team, Department of Emergency Medicine, Tabriz University of Medical Sciences, 5166614756 Tabriz, Iran.

DOI: https://doi.org/10.15586/jrenhep.2019.49
Journal volume & issue: Vol. 3, no. 1

Abstract

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Stearoyl-coenzyme A desaturase 1 (SCD1) is a microsomal enzyme that controls fatty acid metabolism and is highly expressed in hepatocytes. SCD1 may play a key role in liver development and hepatic lipid homeostasis through promoting monounsaturated protein acylation and converting lipotoxic saturated fatty acids into monounsaturated fatty acids. Imbalanced activity of SCD1 has been implicated in fatty liver induction, inflammation and stress. In this review, the role of SCD1 in hepatic development, function and pathogenesis is discussed. Additionally, emerging novel therapeutic agents targeting SCD1 for the treatment of liver disorders are presented.

Published in Journal of Renal and Hepatic Disorders

ISSN: 2207-3744 (Online)
Publisher: Codon Publications
Country of publisher: Australia
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the endocrine glands. Clinical endocrinology; Medicine: Internal medicine: Specialties of internal medicine: Diseases of the genitourinary system. Urology
Website: https://jrenhep.com/index.php/jrenhep

About the journal

Abstract

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