Src family kinases Fyn and Lyn are constitutively activated and mediate plasmacytoid dendritic cell responses

S. Dallari; M. Macal; M. E. Loureiro; Y. Jo; L. Swanson; C. Hesser; P. Ghosh; E. I. Zuniga

doi:10.1038/ncomms14830

Nature Communications (Apr 2017)

Src family kinases Fyn and Lyn are constitutively activated and mediate plasmacytoid dendritic cell responses

S. Dallari,
M. Macal,
M. E. Loureiro,
Y. Jo,
L. Swanson,
C. Hesser,
P. Ghosh,
E. I. Zuniga

Affiliations

S. Dallari: Division of Biological Sciences, Molecular Biology Section, University of California
M. Macal: Division of Biological Sciences, Molecular Biology Section, University of California
M. E. Loureiro: Division of Biological Sciences, Molecular Biology Section, University of California
Y. Jo: Division of Biological Sciences, Molecular Biology Section, University of California
L. Swanson: Departments of Medicine and Cellular and Molecular Medicine, University of California
C. Hesser: Division of Biological Sciences, Molecular Biology Section, University of California
P. Ghosh: Departments of Medicine and Cellular and Molecular Medicine, University of California
E. I. Zuniga: Division of Biological Sciences, Molecular Biology Section, University of California

DOI: https://doi.org/10.1038/ncomms14830
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 16

Abstract

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Type I interferon responses are a core immunoregulatory function of plasmacytoid dendritic cells (pDCs). Here the authors show that SFK family members, including Lyn and Fyn, control type I interferon production in human and mouse pDCs.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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