The paper includes the results of laboratory studies for the copper-bearing ore flotation with the use of a combined reagent. The combined flotation reagent was preliminarily passed through a UZDN-A1200T ultrasonic disperser before flotation to obtain a reagent microemulsion. The copper content in the concentrate was 21,5 % with extraction of 83,3 % in a closed cycle in the base mode. It was 21,8 % with an extraction of 88,3 % when a combined flotation reagent was used. There is an increase in copper extraction by 5 %. The combined reagent consumption is reduced by 15 % compared to the main technology.