S100A6 and c-Kit-Positive Spindle Cell Melanoma of the Dorsal Foot

Abstract

Spindle cell melanoma, which is a rare form of melanoma, is clinically and histopathologically difficult to diagnose from a variety of nonmelanocytic spindle cell tumors. We describe a 42-year-old Japanese woman with amelanotic melanoma that comprised spindle cells with positive c-kit and S100A6 staining. The use of c-kit and S100A6 might be useful for improving the diagnosis.

Keywords

• Spindle cell melanoma
• Differential diagnosis
• S100A6
• c-Kit