F1000Research (Oct 2020)

AlignmentViewer: Sequence Analysis of Large Protein Families [version 2; peer review: 2 approved]

  • Roc Reguant,
  • Yevgeniy Antipin,
  • Rob Sheridan,
  • Christian Dallago,
  • Drew Diamantoukos,
  • Augustin Luna,
  • Chris Sander,
  • Nicholas Paul Gauthier

DOI
https://doi.org/10.12688/f1000research.22242.2
Journal volume & issue
Vol. 9

Abstract

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AlignmentViewer is a web-based tool to view and analyze multiple sequence alignments of protein families. The particular strengths of AlignmentViewer include flexible visualization at different scales as well as analysis of conservation patterns and of the distribution of proteins in sequence space. The tool is directly accessible in web browsers without the need for software installation. It can handle protein families with tens of thousands of sequences and is particularly suitable for evolutionary coupling analysis, e.g. via EVcouplings.org.