Association of Novelty Seeking Scores and Striatal Dopamine D2/D3 Receptor Availability of Healthy Volunteers: Single Photon Emission Computed Tomography With 123I-iodobenzamide

Hsiang Yu Huang; I Hui Lee; Kao Ching Chen; Tzung Lieh Yeh; Po See Chen; Yen Kuang Yang; Nan-Tsing Chiu; We Jen Yao; Chia-Chieh Chen

doi:10.1016/S0929-6646(10)60119-2

Journal of the Formosan Medical Association (Oct 2010)

Association of Novelty Seeking Scores and Striatal Dopamine D2/D3 Receptor Availability of Healthy Volunteers: Single Photon Emission Computed Tomography With 123I-iodobenzamide

Hsiang Yu Huang,
I Hui Lee,
Kao Ching Chen,
Tzung Lieh Yeh,
Po See Chen,
Yen Kuang Yang,
Nan-Tsing Chiu,
We Jen Yao,
Chia-Chieh Chen

Affiliations

Hsiang Yu Huang: Department of Psychiatry, National Cheng Kung University Hospital, Tainan, Taiwan
I Hui Lee: Department of Psychiatry, National Cheng Kung University Hospital, Tainan, Taiwan
Kao Ching Chen: Department of Psychiatry, National Cheng Kung University Hospital, Tainan, Taiwan
Tzung Lieh Yeh: Department of Psychiatry, National Cheng Kung University Hospital, Tainan, Taiwan
Po See Chen: Department of Psychiatry, National Cheng Kung University Hospital, Tainan, Taiwan
Yen Kuang Yang: Department of Psychiatry, National Cheng Kung University Hospital, Tainan, Taiwan
Nan-Tsing Chiu: Department of Nuclear Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan
We Jen Yao: Department of Nuclear Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan
Chia-Chieh Chen: Institute of Nuclear Energy Research, Atomic Energy Council, Executive Yuan, Taoyun, Taiwan

DOI: https://doi.org/10.1016/S0929-6646(10)60119-2
Journal volume & issue: Vol. 109, no. 10
pp. 736 – 739

Abstract

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It has been speculated that novelty seeking (NS) behavior is related to the dopaminergic system. Fifty-two subjects completed the Tridimensional Personality Questionnaire and underwent single photon emission computed tomography with 123I-iodobenzamide. A marginally positive correlation was noted between NS and striatal dopamine D2/D3 receptor availability (r = 0.25, p =0.07). A positive association was noted between the NS scores and left striatal D2/D3 receptor availability (r= 0.29, p =0.04). The results suggest that a relationship might exist between NS score and dopaminergic activity.

Published in Journal of the Formosan Medical Association

ISSN: 0929-6646 (Print)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Medicine (General)
Website: http://www.journals.elsevier.com/journal-of-the-formosan-medical-association/

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