Nature Communications (Feb 2022)
Rare SLC13A1 variants associate with intervertebral disc disorder highlighting role of sulfate in disc pathology
- Gyda Bjornsdottir,
- Lilja Stefansdottir,
- Gudmar Thorleifsson,
- Patrick Sulem,
- Kristjan Norland,
- Egil Ferkingstad,
- Asmundur Oddsson,
- Florian Zink,
- Sigrun H. Lund,
- Muhammad S. Nawaz,
- G. Bragi Walters,
- Astros Th. Skuladottir,
- Sigurjon A. Gudjonsson,
- Gudmundur Einarsson,
- Gisli H. Halldorsson,
- Valgerdur Bjarnadottir,
- Gardar Sveinbjornsson,
- Anna Helgadottir,
- Unnur Styrkarsdottir,
- Larus J. Gudmundsson,
- Ole B. Pedersen,
- Thomas Folkmann Hansen,
- Thomas Werge,
- Karina Banasik,
- Anders Troelsen,
- Soren T. Skou,
- Lise Wegner Thørner,
- Christian Erikstrup,
- Kaspar Rene Nielsen,
- Susan Mikkelsen,
- DBDS Genetic Consortium,
- GO Consortium,
- Ingileif Jonsdottir,
- Aron Bjornsson,
- Ingvar H. Olafsson,
- Elfar Ulfarsson,
- Josep Blondal,
- Arnor Vikingsson,
- Soren Brunak,
- Sisse R. Ostrowski,
- Henrik Ullum,
- Unnur Thorsteinsdottir,
- Hreinn Stefansson,
- Daniel F. Gudbjartsson,
- Thorgeir E. Thorgeirsson,
- Kari Stefansson
Affiliations
- Gyda Bjornsdottir
- deCODE Genetics/Amgen, Inc.
- Lilja Stefansdottir
- deCODE Genetics/Amgen, Inc.
- Gudmar Thorleifsson
- deCODE Genetics/Amgen, Inc.
- Patrick Sulem
- deCODE Genetics/Amgen, Inc.
- Kristjan Norland
- deCODE Genetics/Amgen, Inc.
- Egil Ferkingstad
- deCODE Genetics/Amgen, Inc.
- Asmundur Oddsson
- deCODE Genetics/Amgen, Inc.
- Florian Zink
- deCODE Genetics/Amgen, Inc.
- Sigrun H. Lund
- deCODE Genetics/Amgen, Inc.
- Muhammad S. Nawaz
- deCODE Genetics/Amgen, Inc.
- G. Bragi Walters
- deCODE Genetics/Amgen, Inc.
- Astros Th. Skuladottir
- deCODE Genetics/Amgen, Inc.
- Sigurjon A. Gudjonsson
- deCODE Genetics/Amgen, Inc.
- Gudmundur Einarsson
- deCODE Genetics/Amgen, Inc.
- Gisli H. Halldorsson
- deCODE Genetics/Amgen, Inc.
- Valgerdur Bjarnadottir
- Landspitali University Hospital
- Gardar Sveinbjornsson
- deCODE Genetics/Amgen, Inc.
- Anna Helgadottir
- deCODE Genetics/Amgen, Inc.
- Unnur Styrkarsdottir
- deCODE Genetics/Amgen, Inc.
- Larus J. Gudmundsson
- deCODE Genetics/Amgen, Inc.
- Ole B. Pedersen
- Department of Clinical Immunology, Zealand University Hospital
- Thomas Folkmann Hansen
- Danish Headache Center, Dept. Neurology, Rigshospitalet-Glostrup
- Thomas Werge
- Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen
- Karina Banasik
- Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen
- Anders Troelsen
- Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen
- Soren T. Skou
- Research Unit for Musculoskeletal Function and Physiotherapy, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark
- Lise Wegner Thørner
- Department of Clinical Immunology, Copenhagen University Hospital
- Christian Erikstrup
- Department of Clinical Immunology, Aarhus University Hospital
- Kaspar Rene Nielsen
- Department of Clinical Immunology, Aalborg University Hospital
- Susan Mikkelsen
- Department of Clinical Immunology, Aarhus University Hospital
- DBDS Genetic Consortium
- GO Consortium
- Ingileif Jonsdottir
- deCODE Genetics/Amgen, Inc.
- Aron Bjornsson
- Department of Neurosurgery, Landspitali University Hospital
- Ingvar H. Olafsson
- Department of Neurosurgery, Landspitali University Hospital
- Elfar Ulfarsson
- Department of Neurosurgery, Landspitali University Hospital
- Josep Blondal
- Health Care Institution of West Iceland
- Arnor Vikingsson
- Landspitali University Hospital
- Soren Brunak
- Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen
- Sisse R. Ostrowski
- Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen
- Henrik Ullum
- Statens Serum Institut, Copenhagen
- Unnur Thorsteinsdottir
- deCODE Genetics/Amgen, Inc.
- Hreinn Stefansson
- deCODE Genetics/Amgen, Inc.
- Daniel F. Gudbjartsson
- deCODE Genetics/Amgen, Inc.
- Thorgeir E. Thorgeirsson
- deCODE Genetics/Amgen, Inc.
- Kari Stefansson
- deCODE Genetics/Amgen, Inc.
- DOI
- https://doi.org/10.1038/s41467-022-28167-1
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 13
Abstract
Little is known about the biology of back pain, a leading cause of disability. Here the authors report 30 new back pain loci, implicating genes involved in cartilage/bone biology, as well as neurological and inflammatory processes.
