Nature Communications (Feb 2022)

Rare SLC13A1 variants associate with intervertebral disc disorder highlighting role of sulfate in disc pathology

  • Gyda Bjornsdottir,
  • Lilja Stefansdottir,
  • Gudmar Thorleifsson,
  • Patrick Sulem,
  • Kristjan Norland,
  • Egil Ferkingstad,
  • Asmundur Oddsson,
  • Florian Zink,
  • Sigrun H. Lund,
  • Muhammad S. Nawaz,
  • G. Bragi Walters,
  • Astros Th. Skuladottir,
  • Sigurjon A. Gudjonsson,
  • Gudmundur Einarsson,
  • Gisli H. Halldorsson,
  • Valgerdur Bjarnadottir,
  • Gardar Sveinbjornsson,
  • Anna Helgadottir,
  • Unnur Styrkarsdottir,
  • Larus J. Gudmundsson,
  • Ole B. Pedersen,
  • Thomas Folkmann Hansen,
  • Thomas Werge,
  • Karina Banasik,
  • Anders Troelsen,
  • Soren T. Skou,
  • Lise Wegner Thørner,
  • Christian Erikstrup,
  • Kaspar Rene Nielsen,
  • Susan Mikkelsen,
  • DBDS Genetic Consortium,
  • GO Consortium,
  • Ingileif Jonsdottir,
  • Aron Bjornsson,
  • Ingvar H. Olafsson,
  • Elfar Ulfarsson,
  • Josep Blondal,
  • Arnor Vikingsson,
  • Soren Brunak,
  • Sisse R. Ostrowski,
  • Henrik Ullum,
  • Unnur Thorsteinsdottir,
  • Hreinn Stefansson,
  • Daniel F. Gudbjartsson,
  • Thorgeir E. Thorgeirsson,
  • Kari Stefansson

DOI
https://doi.org/10.1038/s41467-022-28167-1
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 13

Abstract

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Little is known about the biology of back pain, a leading cause of disability. Here the authors report 30 new back pain loci, implicating genes involved in cartilage/bone biology, as well as neurological and inflammatory processes.