Nature Communications (Nov 2017)

ER-associated degradation regulates Alzheimer’s amyloid pathology and memory function by modulating γ-secretase activity

  • Bing Zhu,
  • LuLin Jiang,
  • Timothy Huang,
  • Yingjun Zhao,
  • Tongfei Liu,
  • Yongwang Zhong,
  • Xiaoguang Li,
  • Alexandre Campos,
  • Kenneth Pomeroy,
  • Eliezer Masliah,
  • Dongxian Zhang,
  • Huaxi Xu

DOI
https://doi.org/10.1038/s41467-017-01799-4
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 15

Abstract

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Endoplasmic-reticulum associated degradation (ERAD) regulates protein homeostasis. Here the authors identify an ERAD component membralin, and show that it interacts with a member of the γ-secretase complex to regulate β-amyloid (Aβ) pathology and memory deficits in an Alzheimer’s disease model.