Nature Communications (Mar 2021)
Comprehensive single-cell sequencing reveals the stromal dynamics and tumor-specific characteristics in the microenvironment of nasopharyngeal carcinoma
- Lanqi Gong,
- Dora Lai-Wan Kwong,
- Wei Dai,
- Pingan Wu,
- Shanshan Li,
- Qian Yan,
- Yu Zhang,
- Baifeng Zhang,
- Xiaona Fang,
- Li Liu,
- Min Luo,
- Beilei Liu,
- Larry Ka-Yue Chow,
- Qingyun Chen,
- Jinlin Huang,
- Victor Ho-Fun Lee,
- Ka-On Lam,
- Anthony Wing-Ip Lo,
- Zhiwei Chen,
- Yan Wang,
- Anne Wing-Mui Lee,
- Xin-Yuan Guan
Affiliations
- Lanqi Gong
- Department of Clinical Oncology, The University of Hong Kong-Shenzhen Hospital
- Dora Lai-Wan Kwong
- Department of Clinical Oncology, The University of Hong Kong-Shenzhen Hospital
- Wei Dai
- Department of Clinical Oncology, The University of Hong Kong-Shenzhen Hospital
- Pingan Wu
- Department of Surgery, The University of Hong Kong-Shenzhen Hospital
- Shanshan Li
- Department of Clinical Oncology, The University of Hong Kong-Shenzhen Hospital
- Qian Yan
- Department of Clinical Oncology, The University of Hong Kong-Shenzhen Hospital
- Yu Zhang
- Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Baifeng Zhang
- Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Xiaona Fang
- Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Li Liu
- Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Min Luo
- Department of Clinical Oncology, The University of Hong Kong-Shenzhen Hospital
- Beilei Liu
- Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Larry Ka-Yue Chow
- Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Qingyun Chen
- State Key Laboratory of Oncology in Southern China, Sun Yat-sen University Cancer Center
- Jinlin Huang
- Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Victor Ho-Fun Lee
- Department of Clinical Oncology, The University of Hong Kong-Shenzhen Hospital
- Ka-On Lam
- Department of Clinical Oncology, The University of Hong Kong-Shenzhen Hospital
- Anthony Wing-Ip Lo
- Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Zhiwei Chen
- Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Yan Wang
- Department of Pathology, The University of Hong Kong-Shenzhen Hospital
- Anne Wing-Mui Lee
- Department of Clinical Oncology, The University of Hong Kong-Shenzhen Hospital
- Xin-Yuan Guan
- Department of Clinical Oncology, The University of Hong Kong-Shenzhen Hospital
- DOI
- https://doi.org/10.1038/s41467-021-21795-z
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 18
Abstract
The tumor microenvironment can influence patient survival response to therapy. Here, the authors used single-cell sequencing to investigate the microenvironment of nasopharyngeal cancer and identify tumor-specific signatures in five stromal clusters of cells that may influence patient survival.
