Nature Communications (Feb 2022)
ATF-4 and hydrogen sulfide signalling mediate longevity in response to inhibition of translation or mTORC1
- Cyril Statzer,
- Jin Meng,
- Richard Venz,
- Monet Bland,
- Stacey Robida-Stubbs,
- Krina Patel,
- Dunja Petrovic,
- Raffaella Emsley,
- Pengpeng Liu,
- Ianessa Morantte,
- Cole Haynes,
- William B. Mair,
- Alban Longchamp,
- Milos R. Filipovic,
- T. Keith Blackwell,
- Collin Y. Ewald
Affiliations
- Cyril Statzer
- Eidgenössische Technische Hochschule Zürich, Department of Health Sciences and Technology, Institute of Translational Medicine
- Jin Meng
- Department of Genetics, Harvard Medical School
- Richard Venz
- Eidgenössische Technische Hochschule Zürich, Department of Health Sciences and Technology, Institute of Translational Medicine
- Monet Bland
- Department of Genetics, Harvard Medical School
- Stacey Robida-Stubbs
- Department of Genetics, Harvard Medical School
- Krina Patel
- Department of Genetics, Harvard Medical School
- Dunja Petrovic
- Leibniz-Institut für Analytische Wissenschaften-ISAS-e.V.
- Raffaella Emsley
- Department of Vascular Surgery, Centre Hospitalier Universitaire Vaudois and University of Lausanne
- Pengpeng Liu
- Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School
- Ianessa Morantte
- Department of Genetics and Complex Diseases, Harvard School of Public Health
- Cole Haynes
- Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School
- William B. Mair
- Department of Genetics and Complex Diseases, Harvard School of Public Health
- Alban Longchamp
- Department of Vascular Surgery, Centre Hospitalier Universitaire Vaudois and University of Lausanne
- Milos R. Filipovic
- Leibniz-Institut für Analytische Wissenschaften-ISAS-e.V.
- T. Keith Blackwell
- Department of Genetics, Harvard Medical School
- Collin Y. Ewald
- Eidgenössische Technische Hochschule Zürich, Department of Health Sciences and Technology, Institute of Translational Medicine
- DOI
- https://doi.org/10.1038/s41467-022-28599-9
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 15
Abstract
The authors showed that, in C. elegans, inhibition of translation or mTORC1 increases ATF-4 expression independently of ISR signalling. ATF-4 promotes longevity by increasing hydrogen sulfide production by the enzyme CTH-2.
