Iterative Chemical Engineering of Vancomycin Leads to Novel Vancomycin Analogs With a High in Vitro Therapeutic Index

• Nigam M. Mishra,
• Izabela Stolarzewicz,
• Izabela Stolarzewicz,
• David Cannaerts,
• Joris Schuermans,
• Rob Lavigne,
• Yannick Looz,
• Bart Landuyt,
• Liliane Schoofs,
• Dominique Schols,
• Jan Paeshuyse,
• Peter Hickenbotham,
• Martha Clokie,
• Walter Luyten,
• Walter Luyten,
• Erik V. Van der Eycken,
• Erik V. Van der Eycken,
• Yves Briers,
• Yves Briers

Affiliations

Nigam M. Mishra

Laboratory for Organic and Microwave-Assisted Chemistry, Department of Chemistry, KU Leuven, Leuven, Belgium

Izabela Stolarzewicz

Laboratory for Organic and Microwave-Assisted Chemistry, Department of Chemistry, KU Leuven, Leuven, Belgium

Izabela Stolarzewicz

Department of Chemistry, Warsaw University of Life Sciences, Warsaw, Poland

David Cannaerts

Laboratory for Organic and Microwave-Assisted Chemistry, Department of Chemistry, KU Leuven, Leuven, Belgium

Joris Schuermans

Laboratory of Gene Technology, Department of Biosystems, KU Leuven, Leuven, Belgium

Rob Lavigne

Laboratory of Gene Technology, Department of Biosystems, KU Leuven, Leuven, Belgium

Yannick Looz

Laboratory of Functional Genomics and Proteomics, Department of Biology, KU Leuven, Leuven, Belgium

Bart Landuyt

Laboratory of Functional Genomics and Proteomics, Department of Biology, KU Leuven, Leuven, Belgium

Liliane Schoofs

Laboratory of Functional Genomics and Proteomics, Department of Biology, KU Leuven, Leuven, Belgium

Dominique Schols

Laboratory of Virology and Chemotherapy, Rega Institute, Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium

Jan Paeshuyse

Laboratory for Host Pathogen Interactions, Department of Biosystems, KU Leuven, Leuven, Belgium

Peter Hickenbotham

Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom

Martha Clokie

Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom

Walter Luyten

Laboratory of Functional Genomics and Proteomics, Department of Biology, KU Leuven, Leuven, Belgium

Walter Luyten

Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium

Erik V. Van der Eycken

Laboratory for Organic and Microwave-Assisted Chemistry, Department of Chemistry, KU Leuven, Leuven, Belgium

Erik V. Van der Eycken

Department of Organic Chemistry, Peoples’ Friendship University of Russia (RUDN University), Moscow, Russia

Yves Briers

Laboratory of Gene Technology, Department of Biosystems, KU Leuven, Leuven, Belgium

Yves Briers

0Laboratory of Applied Biotechnology, Department of Biotechnology, Ghent University, Ghent, Belgium