Downregulation of tumor-suppressor gene LHX6 in cancer: a systematic review

Abstract

Introduction. LIM Homeobox 6 (LHX6) encodes a LIM homeodomain transcription factor, contributes to tissue development and morphogenesis, and is mostly expressed in medial ganglionic eminence and odontogenic mesenchyme. However, it has been reported to play a role in cancer progression. This narrative review summarizes literatures that emphasize the molecular regulation of LHX6 in tumorigenesis.

Keywords

• lhx6
• cancer progression
• epigenetics
• tumor suppressor gene
• prognostic biomarker