Nature Communications (Jan 2021)
SARS-CoV-2 induces robust germinal center CD4 T follicular helper cell responses in rhesus macaques
- Yashavanth Shaan Lakshmanappa,
- Sonny R. Elizaldi,
- Jamin W. Roh,
- Brian A. Schmidt,
- Timothy D. Carroll,
- Kourtney D. Weaver,
- Justin C. Smith,
- Anil Verma,
- Jesse D. Deere,
- Joseph Dutra,
- Mars Stone,
- Sergej Franz,
- Rebecca Lee Sammak,
- Katherine J. Olstad,
- J. Rachel Reader,
- Zhong-Min Ma,
- Nancy K. Nguyen,
- Jennifer Watanabe,
- Jodie Usachenko,
- Ramya Immareddy,
- JoAnn L. Yee,
- Daniela Weiskopf,
- Alessandro Sette,
- Dennis Hartigan-O’Connor,
- Stephen J. McSorley,
- John H. Morrison,
- Nam K. Tran,
- Graham Simmons,
- Michael P. Busch,
- Pamela A. Kozlowski,
- Koen K. A. Van Rompay,
- Christopher J. Miller,
- Smita S. Iyer
Affiliations
- Yashavanth Shaan Lakshmanappa
- Center for Immunology and Infectious Diseases, UC Davis
- Sonny R. Elizaldi
- Center for Immunology and Infectious Diseases, UC Davis
- Jamin W. Roh
- Center for Immunology and Infectious Diseases, UC Davis
- Brian A. Schmidt
- Center for Immunology and Infectious Diseases, UC Davis
- Timothy D. Carroll
- California National Primate Research Center, UC Davis
- Kourtney D. Weaver
- Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center
- Justin C. Smith
- Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center
- Anil Verma
- Center for Immunology and Infectious Diseases, UC Davis
- Jesse D. Deere
- California National Primate Research Center, UC Davis
- Joseph Dutra
- California National Primate Research Center, UC Davis
- Mars Stone
- Department of Laboratory Medicine, University of California
- Sergej Franz
- Vitalant Research Institute
- Rebecca Lee Sammak
- California National Primate Research Center, UC Davis
- Katherine J. Olstad
- California National Primate Research Center, UC Davis
- J. Rachel Reader
- California National Primate Research Center, UC Davis
- Zhong-Min Ma
- California National Primate Research Center, UC Davis
- Nancy K. Nguyen
- Center for Immunology and Infectious Diseases, UC Davis
- Jennifer Watanabe
- California National Primate Research Center, UC Davis
- Jodie Usachenko
- California National Primate Research Center, UC Davis
- Ramya Immareddy
- California National Primate Research Center, UC Davis
- JoAnn L. Yee
- California National Primate Research Center, UC Davis
- Daniela Weiskopf
- Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology
- Alessandro Sette
- Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology
- Dennis Hartigan-O’Connor
- California National Primate Research Center, UC Davis
- Stephen J. McSorley
- Center for Immunology and Infectious Diseases, UC Davis
- John H. Morrison
- California National Primate Research Center, UC Davis
- Nam K. Tran
- Pathology and Laboratory Medicine, School of Medicine, UC Davis
- Graham Simmons
- Department of Laboratory Medicine, University of California
- Michael P. Busch
- Department of Laboratory Medicine, University of California
- Pamela A. Kozlowski
- Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center
- Koen K. A. Van Rompay
- California National Primate Research Center, UC Davis
- Christopher J. Miller
- Center for Immunology and Infectious Diseases, UC Davis
- Smita S. Iyer
- Center for Immunology and Infectious Diseases, UC Davis
- DOI
- https://doi.org/10.1038/s41467-020-20642-x
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 14
Abstract
Induction of CD4 T follicular helper (Tfh) cells is important for antibody responses to viral infections. Here, the authors show in a rhesus macaque model of mild COVID-19 that SARS-CoV-2 infection results in transient accumulation of proliferating Tfh cells with a Th1 profile in peripheral blood and generation of germinal center Tfh cells specific for viral proteins.
