Open Medicine (Sep 2021)
GJA1 promotes hepatocellular carcinoma progression by mediating TGF-β-induced activation and the epithelial–mesenchymal transition of hepatic stellate cells
- Niu Gengming,
- Zhang Xiaotian,
- Hong Runqi,
- Yang Ximin,
- Gu Jiawei,
- Song Tao,
- Hu Zhiqing,
- Chen Liang,
- Wang Xin,
- Xia Jie,
- Ke Zhongwei,
- Ren Jun,
- Hong Liang
Affiliations
- Niu Gengming
- Department of General Surgery, Shanghai Fifth People’s Hospital, Fudan University, Minhang District, Shanghai, 200240, People’s Republic of China
- Zhang Xiaotian
- Department of General Surgery, Shanghai Fifth People’s Hospital, Fudan University, Minhang District, Shanghai, 200240, People’s Republic of China
- Hong Runqi
- Department of General Surgery, Shanghai Fifth People’s Hospital, Fudan University, Minhang District, Shanghai, 200240, People’s Republic of China
- Yang Ximin
- Department of Radiology, Dongying New District Hospital, Dongying, Shandong Province, 257000, People’s Republic of China
- Gu Jiawei
- Department of General Surgery, Shanghai Fifth People’s Hospital, Fudan University, Minhang District, Shanghai, 200240, People’s Republic of China
- Song Tao
- Department of General Surgery, Shanghai Fifth People’s Hospital, Fudan University, Minhang District, Shanghai, 200240, People’s Republic of China
- Hu Zhiqing
- Department of General Surgery, Shanghai Fifth People’s Hospital, Fudan University, Minhang District, Shanghai, 200240, People’s Republic of China
- Chen Liang
- Department of General Surgery, Shanghai Fifth People’s Hospital, Fudan University, Minhang District, Shanghai, 200240, People’s Republic of China
- Wang Xin
- Department of General Surgery, Shanghai Fifth People’s Hospital, Fudan University, Minhang District, Shanghai, 200240, People’s Republic of China
- Xia Jie
- Department of General Surgery, Shanghai Fifth People’s Hospital, Fudan University, Minhang District, Shanghai, 200240, People’s Republic of China
- Ke Zhongwei
- Department of General Surgery, Shanghai Fifth People’s Hospital, Fudan University, 801 Heqing Road, Minhang District, Shanghai, 200240, People’s Republic of China
- Ren Jun
- Department of General Surgery, Shanghai Fifth People’s Hospital, Fudan University, 801 Heqing Road, Minhang District, Shanghai, 200240, People’s Republic of China
- Hong Liang
- Department of General Surgery, Shanghai Fifth People’s Hospital, Fudan University, 801 Heqing Road, Minhang District, Shanghai, 200240, People’s Republic of China
- DOI
- https://doi.org/10.1515/med-2021-0344
- Journal volume & issue
-
Vol. 16,
no. 1
pp. 1459 – 1471
Abstract
Gap junction protein, alpha 1 (GJA1), which is correlated with recurrences and unfavorable prognoses in hepatocellular carcinomas (HCCs), is one of the specific proteins expressed by activated hepatic stellate cells (HSCs).
Keywords
