Nature Communications (Oct 2022)
A hypothalamic dopamine locus for psychostimulant-induced hyperlocomotion in mice
- Solomiia Korchynska,
- Patrick Rebernik,
- Marko Pende,
- Laura Boi,
- Alán Alpár,
- Ramon Tasan,
- Klaus Becker,
- Kira Balueva,
- Saiedeh Saghafi,
- Peer Wulff,
- Tamas L. Horvath,
- Gilberto Fisone,
- Hans-Ulrich Dodt,
- Tomas Hökfelt,
- Tibor Harkany,
- Roman A. Romanov
Affiliations
- Solomiia Korchynska
- Department of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna
- Patrick Rebernik
- Department of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna
- Marko Pende
- Section for Bioelectronics, Center for Brain Research, Medical University of Vienna
- Laura Boi
- Department of Neuroscience, Biomedicum, Karolinska Institutet
- Alán Alpár
- Department of Anatomy, Semmelweis University
- Ramon Tasan
- Department of Pharmacology, Medical University Innsbruck
- Klaus Becker
- Section for Bioelectronics, Center for Brain Research, Medical University of Vienna
- Kira Balueva
- Institute of Physiology, Christian-Albrechts-University
- Saiedeh Saghafi
- Department of Bioelectronics, Institute of Solid State Electronics, Technical University of Vienna
- Peer Wulff
- Institute of Physiology, Christian-Albrechts-University
- Tamas L. Horvath
- Department of Neuroscience, Department of Comparative Medicine, Yale School of Medicine
- Gilberto Fisone
- Department of Neuroscience, Biomedicum, Karolinska Institutet
- Hans-Ulrich Dodt
- Section for Bioelectronics, Center for Brain Research, Medical University of Vienna
- Tomas Hökfelt
- Department of Neuroscience, Biomedicum, Karolinska Institutet
- Tibor Harkany
- Department of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna
- Roman A. Romanov
- Department of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna
- DOI
- https://doi.org/10.1038/s41467-022-33584-3
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 16
Abstract
The psychostimulant-sensitive neural mechanism linking the circadian clock to locomotion is unknown. Here, hypothalamic A14 neurons are shown to time diurnal activity by entraining the lateral septum, and their activity is shown to be sensitive to amphetamine.
