Recapitulation of HDV infection in a fully permissive hepatoma cell line allows efficient drug evaluation

Florian A. Lempp; Franziska Schlund; Lisa Rieble; Lea Nussbaum; Corinna Link; Zhenfeng Zhang; Yi Ni; Stephan Urban

doi:10.1038/s41467-019-10211-2

Nature Communications (May 2019)

Recapitulation of HDV infection in a fully permissive hepatoma cell line allows efficient drug evaluation

Florian A. Lempp,
Franziska Schlund,
Lisa Rieble,
Lea Nussbaum,
Corinna Link,
Zhenfeng Zhang,
Yi Ni,
Stephan Urban

Affiliations

Florian A. Lempp: Department of Infectious Diseases, Molecular Virology, University Hospital Heidelberg
Franziska Schlund: Department of Infectious Diseases, Molecular Virology, University Hospital Heidelberg
Lisa Rieble: Department of Infectious Diseases, Molecular Virology, University Hospital Heidelberg
Lea Nussbaum: Department of Infectious Diseases, Molecular Virology, University Hospital Heidelberg
Corinna Link: Department of Infectious Diseases, Molecular Virology, University Hospital Heidelberg
Zhenfeng Zhang: Department of Infectious Diseases, Molecular Virology, University Hospital Heidelberg
Yi Ni: Department of Infectious Diseases, Molecular Virology, University Hospital Heidelberg
Stephan Urban: Department of Infectious Diseases, Molecular Virology, University Hospital Heidelberg

DOI: https://doi.org/10.1038/s41467-019-10211-2
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 11

Abstract

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Hepatitis delta virus (HDV) depends on the envelope proteins of hepatitis B virus (HBV) for virion production. Here, Lempp et al. produce a cell line expressing HBV envelope proteins and their receptor, which allows continuous secretion of infectious progeny HDV and testing of antiviral drugs.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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