The Relationship Between APACHE II Score and Immunological Parameters in Intensive Care Patients

Abstract

INTRODUCTION: In this study, the aim was to investigate the relationship between immunological parameters, specifically the fibrinogen/albumin ratio, neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, and the widely used acute physiology and chronic health assessment (APACHE) II scoring system in critically ill patients in the intensive care unit. METHODS: The retrospective analysis included 166 patients admitted between January 2023 and July 2023, evaluating their 28-day mortality. The patients were categorised into groups: Group M (mortality), with 53 patients and Group S (survival) with 113 patients. The immunological parameters of the patients between the groups were analyzed statistically. RESULTS: APACHE II score, fibrinogen, lactate, and fibrinogen/albumin ratio were identified as independent parameters associated with mortality. The ROC analysis determined the optimal cutoff points for predicting mortality for APACHE II score, fibrinogen, lactate, and fibrinogen/albumin ratio. DISCUSSION AND CONCLUSION: This study revealed a significant correlation between APACHE II score and immunological parameters, including fibrinogen, lactate, and fibrinogen/albumin ratio. These findings can be used to predict mortality.

Keywords

• apache ii score
• immunological parameters
• intensive care unit
• mortality