Терапевтический архив (Oct 2009)

Relationship between the intima-media complex thickness, the risk factors of cardiovascular diseases, and the level of C-reactive protein in gouty patients

  • Anna Evgen'evna Il'ina,
  • Evgeniya Innokent'evna Varfolomeeva,
  • Aleksandr Viktorovich Volkov,
  • Evelina Semenovna Mach,
  • Elena Nikolaevna Aleksandrova,
  • Aleksandr Aleksandrovich Novikov,
  • Ekaterina Valerievna Il'inykh,
  • Viktoriya Georgievna Barskova,
  • Evgeniy L'vovich Nasonov,
  • A E Ilyina,
  • E I Varfolomeyeva,
  • A V Volkov,
  • E S Mach,
  • E N Aleksandrova,
  • A A Novikov,
  • E V Ilyinykh,
  • V G Barskova,
  • E L Nasonov

Journal volume & issue
Vol. 81, no. 10
pp. 45 – 49

Abstract

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Aim. To estimate a relationship between the intima-media thickness (TIM), cardiovascular risk (CVR) factors, and the level of C-reactive protein (CRP) in gouty patients. Subjects and methods. Eighty-nine patients at an interattack interval were examined. The patients' mean age was 46.0 ± 11.4 years; the duration of the disease was 5.2 (3.0; 8.9) years. The traditional CVR factors were analyzed. Carotid ultrasound scanning was performed to detect vascular atherosclerotic lesion. The serum CRP concentration was measured by a highly sensitive immunonefelometric assay. Results. According to the TIM, the patients were divided into 2 groups: 1) 37 patients with signs of carotid atherosclerotic lesion (TIM l 0.9 mm); 2) 52 patients with a TIM of less than 0.9 mm. The ages at the moment of examination and at the onset of the disease, the duration of the disease, as well as systolic blood pressure, and the risk of myocardial ischemia were greater in Group 1 than those in Group 2. In patients with atherosclerosis, the concentration of CRP was statistically significantly higher than that in patients without this condition. Conclusion. By complementing the classical CVR factors, CRP may be a predictor of cardiovaskular diseases and their complications in patients with gout at an interattack interval.

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