Nature Communications (Jul 2017)
Deciphering minimal antigenic epitopes associated with Burkholderia pseudomallei and Burkholderia mallei lipopolysaccharide O-antigens
- Marielle Tamigney Kenfack,
- Marcelina Mazur,
- Teerapat Nualnoi,
- Teresa L. Shaffer,
- Abba Ngassimou,
- Yves Blériot,
- Jérôme Marrot,
- Roberta Marchetti,
- Kitisak Sintiprungrat,
- Narisara Chantratita,
- Alba Silipo,
- Antonio Molinaro,
- David P. AuCoin,
- Mary N. Burtnick,
- Paul J. Brett,
- Charles Gauthier
Affiliations
- Marielle Tamigney Kenfack
- Institut de Chimie IC2MP, CNRS-UMR 7285, Équipe Synthèse Organique, Groupe Glycochimie, Université de Poitiers
- Marcelina Mazur
- Institut de Chimie IC2MP, CNRS-UMR 7285, Équipe Synthèse Organique, Groupe Glycochimie, Université de Poitiers
- Teerapat Nualnoi
- Department of Microbiology and Immunology, University of Nevada School of Medicine
- Teresa L. Shaffer
- Department of Microbiology and Immunology, University of South Alabama
- Abba Ngassimou
- Institut de Chimie IC2MP, CNRS-UMR 7285, Équipe Synthèse Organique, Groupe Glycochimie, Université de Poitiers
- Yves Blériot
- Institut de Chimie IC2MP, CNRS-UMR 7285, Équipe Synthèse Organique, Groupe Glycochimie, Université de Poitiers
- Jérôme Marrot
- Institut Lavoisier de Versailles, CNRS-UMR 8180, Université de Versailles Saint-Quentin-en-Yvelines, Université Paris-Saclay
- Roberta Marchetti
- Department of Chemical Sciences, Università di Napoli Federico II, Complesso Universitario Monte S. Angelo
- Kitisak Sintiprungrat
- Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University
- Narisara Chantratita
- Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University
- Alba Silipo
- Department of Chemical Sciences, Università di Napoli Federico II, Complesso Universitario Monte S. Angelo
- Antonio Molinaro
- Department of Chemical Sciences, Università di Napoli Federico II, Complesso Universitario Monte S. Angelo
- David P. AuCoin
- Department of Microbiology and Immunology, University of Nevada School of Medicine
- Mary N. Burtnick
- Department of Microbiology and Immunology, University of South Alabama
- Paul J. Brett
- Department of Microbiology and Immunology, University of South Alabama
- Charles Gauthier
- Institut de Chimie IC2MP, CNRS-UMR 7285, Équipe Synthèse Organique, Groupe Glycochimie, Université de Poitiers
- DOI
- https://doi.org/10.1038/s41467-017-00173-8
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 13
Abstract
Melioidosis and glanders are multifaceted infections caused by gram-negative bacteria. Here, the authors synthesize a series of oligosaccharides that mimic the lipopolysaccharides present on the pathogens’ surface and use them to develop novel glycoconjugates for vaccine development.
