Научно-практическая ревматология (Apr 2011)

MOLECULAR GENETIC TESTING OF OSTEOPOROSIS SUSCEPTIBILITY IN POSTMENOPAUSAL WOMEN IN MOSCOW

  • V A Myakotkin,
  • M Yu Krylov,
  • I A Guseva,
  • E V Chetina,
  • N V Toroptsova,
  • O A Nikitinskaya,
  • E Yu Samarkina,
  • L I Benevolenskaya,
  • V A Myakotkin,
  • M Yu Krylov,
  • I A Guseva,
  • E V Chetina,
  • N V Toroptsova,
  • O A Nikitinskaya,
  • E Yu Samarkina,
  • L I Benevolenskaya

DOI
https://doi.org/10.14412/1995-4484-2011-597
Journal volume & issue
Vol. 49, no. 2
pp. 15 – 20

Abstract

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Polymorphisms of 21 genes involved in the processes of bone remodeling were studied on samples of 150 to 265 postmenopausal healthy women in a control group and those of 175 to 269 patients with osteoporosis (OP). In a Moscow sample of postmenopausal women, the genotypes of OP susceptibility were found to be the CT genotype of the low-density lipoprotein receptor-related protein 5 (LRP5) gene, the GG genotype of the leptin (LEP) gene, the XX genotype of the estrogen receptor a (ER-a) gene, the Ff genotype of the vitamin D receptor (VDR) gene, the HH genotype of the a1 polypeptide chain of type II collagen gene and the GG genotype of the aromatase (CYP19) gene. The interaction of a number of genes to develop OP susceptibility was ascertained to be compliant. For example, the carriage of the CTxx genotypes of the LRP5/ERa genes, the CTGG genotypes of the LRP5/CBFA genes, the CCGA genotypes of the TGF/31/CYP19 genes, and the CCAA genotypes of the TGF/31/OPG genes increases a risk for OP by 7.7, 4.1, 6.2, and 2.7 times, respectively. The genotypes increasing the risk of spinal osteoporotic fractures were AG of 163A/G polymorphism in the osteoprotegerin (OPG) gene, TT of 509C^T polymorphism in the TGF/31 gene, and BB of BsmI polymorphism in the VDR gene (OR = 4.9, 3.9, and 4.4, respectively). The genotype of a risk for osteoporotic fractures at other sites was AG of A19G polymorphism in the LEP gene (OR = 2.6).

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