Influence of Chemical Modifications of Polyhydroxyalkanoate-Derived Fatty Acids on Their Antimicrobial Properties

Abstract

Sugar esters are bioactive compounds derived from renewable resources. They consist of a sugar moiety with attached non-polar part − usually a fatty acid. These compounds find uses in cosmetic, food and pharmaceutical industries as surfactants due to their physicochemical and antimicrobial activities. In this study we have produced fatty acids for sugar ester synthesis from bacterially derived polyesters, namely polyhydroxyalkanoates (PHAs). We have developed methodology to decorate PHA monomers with a fluorinated moiety. With aid of biocatalysis a series of glucose esters was created with unmodified and modified PHA monomers. All synthesised compounds showed moderate antimicrobial activity.

Keywords

• polyhydroxyalkanoate
• (<i>R</i>)-3-hydroxyacids
• biocatalysis
• sugar esters
• antimicrobial