Nature Communications (Nov 2018)
The phylogeography and incidence of multi-drug resistant typhoid fever in sub-Saharan Africa
- Se Eun Park,
- Duy Thanh Pham,
- Christine Boinett,
- Vanessa K. Wong,
- Gi Deok Pak,
- Ursula Panzner,
- Ligia Maria Cruz Espinoza,
- Vera von Kalckreuth,
- Justin Im,
- Heidi Schütt-Gerowitt,
- John A. Crump,
- Robert F. Breiman,
- Yaw Adu-Sarkodie,
- Ellis Owusu-Dabo,
- Raphaël Rakotozandrindrainy,
- Abdramane Bassiahi Soura,
- Abraham Aseffa,
- Nagla Gasmelseed,
- Karen H. Keddy,
- Jürgen May,
- Amy Gassama Sow,
- Peter Aaby,
- Holly M. Biggs,
- Julian T. Hertz,
- Joel M. Montgomery,
- Leonard Cosmas,
- Beatrice Olack,
- Barry Fields,
- Nimako Sarpong,
- Tsiriniaina Jean Luco Razafindrabe,
- Tiana Mirana Raminosoa,
- Leon Parfait Kabore,
- Emmanuel Sampo,
- Mekonnen Teferi,
- Biruk Yeshitela,
- Muna Ahmed El Tayeb,
- Arvinda Sooka,
- Christian G. Meyer,
- Ralf Krumkamp,
- Denise Myriam Dekker,
- Anna Jaeger,
- Sven Poppert,
- Adama Tall,
- Aissatou Niang,
- Morten Bjerregaard-Andersen,
- Sandra Valborg Løfberg,
- Hye Jin Seo,
- Hyon Jin Jeon,
- Jessica Fung Deerin,
- Jinkyung Park,
- Frank Konings,
- Mohammad Ali,
- John D. Clemens,
- Peter Hughes,
- Juliet Nsimire Sendagala,
- Tobias Vudriko,
- Robert Downing,
- Usman N. Ikumapayi,
- Grant A. Mackenzie,
- Stephen Obaro,
- Silvia Argimon,
- David M. Aanensen,
- Andrew Page,
- Jacqueline A. Keane,
- Sebastian Duchene,
- Zoe Dyson,
- Kathryn E. Holt,
- Gordon Dougan,
- Florian Marks,
- Stephen Baker
Affiliations
- Se Eun Park
- International Vaccine Institute, SNU Research Park, 1 Gwanak-ro, 1 Gwanak-gu
- Duy Thanh Pham
- The Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit
- Christine Boinett
- The Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit
- Vanessa K. Wong
- Centre for Genomic Pathogen Surveillance, Wellcome Genome Campus, Hinxton
- Gi Deok Pak
- International Vaccine Institute, SNU Research Park, 1 Gwanak-ro, 1 Gwanak-gu
- Ursula Panzner
- International Vaccine Institute, SNU Research Park, 1 Gwanak-ro, 1 Gwanak-gu
- Ligia Maria Cruz Espinoza
- International Vaccine Institute, SNU Research Park, 1 Gwanak-ro, 1 Gwanak-gu
- Vera von Kalckreuth
- International Vaccine Institute, SNU Research Park, 1 Gwanak-ro, 1 Gwanak-gu
- Justin Im
- International Vaccine Institute, SNU Research Park, 1 Gwanak-ro, 1 Gwanak-gu
- Heidi Schütt-Gerowitt
- International Vaccine Institute, SNU Research Park, 1 Gwanak-ro, 1 Gwanak-gu
- John A. Crump
- Kilimanjaro Christian Medical Centre
- Robert F. Breiman
- Centers for Disease Control and Prevention
- Yaw Adu-Sarkodie
- Kwame Nkrumah University of Science and Technology
- Ellis Owusu-Dabo
- Kwame Nkrumah University of Science and Technology
- Raphaël Rakotozandrindrainy
- University of Antananarivo
- Abdramane Bassiahi Soura
- Institut Supérieur des Sciences de la Population, University of Ouagadougou
- Abraham Aseffa
- Armauer Hansen Research Institute
- Nagla Gasmelseed
- Faculty of Medicine, University of Gezira
- Karen H. Keddy
- National Institute for Communicable Diseases
- Jürgen May
- Bernhard Nocht Institute for Tropical Medicine
- Amy Gassama Sow
- Institute Pasteur de Dakar
- Peter Aaby
- Bandim Health Project, Apartado
- Holly M. Biggs
- Kilimanjaro Christian Medical Centre
- Julian T. Hertz
- Kilimanjaro Christian Medical Centre
- Joel M. Montgomery
- Centers for Disease Control and Prevention
- Leonard Cosmas
- Centers for Disease Control and Prevention
- Beatrice Olack
- Kenya Medical Research Institute
- Barry Fields
- Centers for Disease Control and Prevention
- Nimako Sarpong
- Kwame Nkrumah University of Science and Technology
- Tsiriniaina Jean Luco Razafindrabe
- University of Antananarivo
- Tiana Mirana Raminosoa
- University of Antananarivo
- Leon Parfait Kabore
- Schiphra Hospital
- Emmanuel Sampo
- Schiphra Hospital
- Mekonnen Teferi
- Armauer Hansen Research Institute
- Biruk Yeshitela
- Armauer Hansen Research Institute
- Muna Ahmed El Tayeb
- Faculty of Medicine, University of Gezira
- Arvinda Sooka
- National Institute for Communicable Diseases
- Christian G. Meyer
- Institute of Tropical Medicine, Eberhard-Karls University Tübingen, Geschwister-Scholl-Platz
- Ralf Krumkamp
- Bernhard Nocht Institute for Tropical Medicine
- Denise Myriam Dekker
- Bernhard Nocht Institute for Tropical Medicine
- Anna Jaeger
- Bernhard Nocht Institute for Tropical Medicine
- Sven Poppert
- Swiss Tropical and Public Health Institute, University of Basel
- Adama Tall
- Université Cheikh Anta Diop de Dakar
- Aissatou Niang
- Université Cheikh Anta Diop de Dakar
- Morten Bjerregaard-Andersen
- Bandim Health Project, Apartado
- Sandra Valborg Løfberg
- Bandim Health Project, Apartado
- Hye Jin Seo
- International Vaccine Institute, SNU Research Park, 1 Gwanak-ro, 1 Gwanak-gu
- Hyon Jin Jeon
- International Vaccine Institute, SNU Research Park, 1 Gwanak-ro, 1 Gwanak-gu
- Jessica Fung Deerin
- International Vaccine Institute, SNU Research Park, 1 Gwanak-ro, 1 Gwanak-gu
- Jinkyung Park
- International Vaccine Institute, SNU Research Park, 1 Gwanak-ro, 1 Gwanak-gu
- Frank Konings
- International Vaccine Institute, SNU Research Park, 1 Gwanak-ro, 1 Gwanak-gu
- Mohammad Ali
- International Vaccine Institute, SNU Research Park, 1 Gwanak-ro, 1 Gwanak-gu
- John D. Clemens
- International Vaccine Institute, SNU Research Park, 1 Gwanak-ro, 1 Gwanak-gu
- Peter Hughes
- Medical Research Center (MRC)/Uganda Virus Research Institute (UVRI) & London School of Hygiene and Tropical Medicine (LSHTM) Uganda Research Unit
- Juliet Nsimire Sendagala
- Medical Research Center (MRC)/Uganda Virus Research Institute (UVRI) & London School of Hygiene and Tropical Medicine (LSHTM) Uganda Research Unit
- Tobias Vudriko
- Medical Research Center (MRC)/Uganda Virus Research Institute (UVRI) & London School of Hygiene and Tropical Medicine (LSHTM) Uganda Research Unit
- Robert Downing
- Uganda Virus Research Institute (UVRI)
- Usman N. Ikumapayi
- Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Atlantic Boulevard, Fajara
- Grant A. Mackenzie
- Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Atlantic Boulevard, Fajara
- Stephen Obaro
- Division of Pediatric Infectious Diseases, University of Nebraska Medical Center, 42nd and Emile
- Silvia Argimon
- Centre for Genomic Pathogen Surveillance, Wellcome Genome Campus, Hinxton
- David M. Aanensen
- Centre for Genomic Pathogen Surveillance, Wellcome Genome Campus, Hinxton
- Andrew Page
- Centre for Genomic Pathogen Surveillance, Wellcome Genome Campus, Hinxton
- Jacqueline A. Keane
- Centre for Genomic Pathogen Surveillance, Wellcome Genome Campus, Hinxton
- Sebastian Duchene
- Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne
- Zoe Dyson
- Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne
- Kathryn E. Holt
- Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne
- Gordon Dougan
- Centre for Genomic Pathogen Surveillance, Wellcome Genome Campus, Hinxton
- Florian Marks
- International Vaccine Institute, SNU Research Park, 1 Gwanak-ro, 1 Gwanak-gu
- Stephen Baker
- The Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit
- DOI
- https://doi.org/10.1038/s41467-018-07370-z
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 10
Abstract
Typhoid fever is caused by the bacterium Salmonella Typhi. Here, Park et al. analyse the genomes of 249 S. Typhi isolates from 11 sub-Saharan African countries, identifying genes and plasmids associated with antibiotic resistance and showing that multi-drug resistance is highly pervasive in sub-Saharan Africa.
