Nature Communications (Sep 2019)
Retrotransposon insertions can initiate colorectal cancer and are associated with poor survival
- Tatiana Cajuso,
- Päivi Sulo,
- Tomas Tanskanen,
- Riku Katainen,
- Aurora Taira,
- Ulrika A. Hänninen,
- Johanna Kondelin,
- Linda Forsström,
- Niko Välimäki,
- Mervi Aavikko,
- Eevi Kaasinen,
- Ari Ristimäki,
- Selja Koskensalo,
- Anna Lepistö,
- Laura Renkonen-Sinisalo,
- Toni Seppälä,
- Teijo Kuopio,
- Jan Böhm,
- Jukka-Pekka Mecklin,
- Outi Kilpivaara,
- Esa Pitkänen,
- Kimmo Palin,
- Lauri A. Aaltonen
Affiliations
- Tatiana Cajuso
- Applied Tumor Genomics Research Program, Faculty of Medicine University of Helsinki, Biomedicum Helsinki
- Päivi Sulo
- Applied Tumor Genomics Research Program, Faculty of Medicine University of Helsinki, Biomedicum Helsinki
- Tomas Tanskanen
- Applied Tumor Genomics Research Program, Faculty of Medicine University of Helsinki, Biomedicum Helsinki
- Riku Katainen
- Applied Tumor Genomics Research Program, Faculty of Medicine University of Helsinki, Biomedicum Helsinki
- Aurora Taira
- Applied Tumor Genomics Research Program, Faculty of Medicine University of Helsinki, Biomedicum Helsinki
- Ulrika A. Hänninen
- Applied Tumor Genomics Research Program, Faculty of Medicine University of Helsinki, Biomedicum Helsinki
- Johanna Kondelin
- Applied Tumor Genomics Research Program, Faculty of Medicine University of Helsinki, Biomedicum Helsinki
- Linda Forsström
- Applied Tumor Genomics Research Program, Faculty of Medicine University of Helsinki, Biomedicum Helsinki
- Niko Välimäki
- Applied Tumor Genomics Research Program, Faculty of Medicine University of Helsinki, Biomedicum Helsinki
- Mervi Aavikko
- Applied Tumor Genomics Research Program, Faculty of Medicine University of Helsinki, Biomedicum Helsinki
- Eevi Kaasinen
- Applied Tumor Genomics Research Program, Faculty of Medicine University of Helsinki, Biomedicum Helsinki
- Ari Ristimäki
- Applied Tumor Genomics Research Program, Faculty of Medicine University of Helsinki, Biomedicum Helsinki
- Selja Koskensalo
- Department of Gastrointestinal Surgery, Helsinki University Hospital, University of Helsinki
- Anna Lepistö
- Department of Gastrointestinal Surgery, Helsinki University Hospital, University of Helsinki
- Laura Renkonen-Sinisalo
- Department of Gastrointestinal Surgery, Helsinki University Hospital, University of Helsinki
- Toni Seppälä
- Department of Gastrointestinal Surgery, Helsinki University Hospital, University of Helsinki
- Teijo Kuopio
- Biological and Environmental Science, University of Jyväskylä
- Jan Böhm
- Department of Pathology, Central Finland Health Care District
- Jukka-Pekka Mecklin
- Department of Surgery, Jyväskylä Central Hospital
- Outi Kilpivaara
- Applied Tumor Genomics Research Program, Faculty of Medicine University of Helsinki, Biomedicum Helsinki
- Esa Pitkänen
- Applied Tumor Genomics Research Program, Faculty of Medicine University of Helsinki, Biomedicum Helsinki
- Kimmo Palin
- Applied Tumor Genomics Research Program, Faculty of Medicine University of Helsinki, Biomedicum Helsinki
- Lauri A. Aaltonen
- Applied Tumor Genomics Research Program, Faculty of Medicine University of Helsinki, Biomedicum Helsinki
- DOI
- https://doi.org/10.1038/s41467-019-11770-0
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 9
Abstract
Retrotransposons are usually dormant in healthy tissue, but become activated during malignancy. Here, in colorectal cancer, Cajuso et al. show that retrotransposon activity associates with clinical features of the disease.
