Nature Communications (Nov 2022)
mTORC1 links pathology in experimental models of Still’s disease and macrophage activation syndrome
- Zhengping Huang,
- Xiaomeng You,
- Liang Chen,
- Yan Du,
- Kailey Brodeur,
- Hyuk Jee,
- Qiang Wang,
- Grace Linder,
- Roxane Darbousset,
- Pierre Cunin,
- Margaret H. Chang,
- Alexandra Wactor,
- Brian M. Wauford,
- Marc J. C. Todd,
- Kevin Wei,
- Ying Li,
- Anais Levescot,
- Yoichiro Iwakura,
- Virginia Pascual,
- Nicole E. Baldwin,
- Pierre Quartier,
- Tianwang Li,
- Maria T. Gianatasio,
- Robert P. Hasserjian,
- Lauren A. Henderson,
- David B. Sykes,
- Elizabeth D. Mellins,
- Scott W. Canna,
- Julia F. Charles,
- Peter A. Nigrovic,
- Pui Y. Lee
Affiliations
- Zhengping Huang
- Division of Immunology, Boston Children’s Hospital, Harvard Medical School
- Xiaomeng You
- Department of Orthopaedic Surgery, Brigham and Women’s Hospital, Harvard Medical School
- Liang Chen
- Division of Immunology, Boston Children’s Hospital, Harvard Medical School
- Yan Du
- Division of Immunology, Boston Children’s Hospital, Harvard Medical School
- Kailey Brodeur
- Division of Immunology, Boston Children’s Hospital, Harvard Medical School
- Hyuk Jee
- Division of Immunology, Boston Children’s Hospital, Harvard Medical School
- Qiang Wang
- Division of Immunology, Boston Children’s Hospital, Harvard Medical School
- Grace Linder
- Blood Bank and Transfusion Medicine Division, Children’s Hospital of Philadelphia
- Roxane Darbousset
- Division of Immunology, Boston Children’s Hospital, Harvard Medical School
- Pierre Cunin
- Division of Immunology, Boston Children’s Hospital, Harvard Medical School
- Margaret H. Chang
- Division of Immunology, Boston Children’s Hospital, Harvard Medical School
- Alexandra Wactor
- Division of Immunology, Boston Children’s Hospital, Harvard Medical School
- Brian M. Wauford
- Division of Immunology, Boston Children’s Hospital, Harvard Medical School
- Marc J. C. Todd
- Division of Immunology, Boston Children’s Hospital, Harvard Medical School
- Kevin Wei
- Division of Rheumatology, Inflammation, and Immunity, Brigham and Women’s Hospital, Harvard Medical School
- Ying Li
- Division of Rheumatology, Inflammation, and Immunity, Brigham and Women’s Hospital, Harvard Medical School
- Anais Levescot
- Université Paris Cité, Institut Imagine, INSERM UMR1163, Laboratory Intestinal Immunity
- Yoichiro Iwakura
- Centre for Animal Disease Models, Research Institute for Biomedical Sciences, Tokyo University of Science
- Virginia Pascual
- Department of Pediatrics and Drukier Institute for Children’s Health, Weill Cornell Medicine
- Nicole E. Baldwin
- Baylor Scott & White Research Institute
- Pierre Quartier
- Pediatric Immunology, Hematology and Rheumatology Unit, Necker-Enfants Malades Hospital, Assistance Publique-Hopitaux de Paris, Universite de Paris
- Tianwang Li
- Department of Rheumatology and Immunology, Guangdong Second Provincial General Hospital
- Maria T. Gianatasio
- Mass General Brigham Healthcare Center - Salem Hospital
- Robert P. Hasserjian
- Department of Pathology, Massachusetts General Hospital, Harvard Medical School
- Lauren A. Henderson
- Division of Immunology, Boston Children’s Hospital, Harvard Medical School
- David B. Sykes
- Center for Regenerative Medicine, Massachusetts General Hospital
- Elizabeth D. Mellins
- Department of Pediatrics, Program in Immunology, Stanford University
- Scott W. Canna
- Division of Rheumatology, Children’s Hospital of Philadelphia
- Julia F. Charles
- Division of Rheumatology, Inflammation, and Immunity, Brigham and Women’s Hospital, Harvard Medical School
- Peter A. Nigrovic
- Division of Immunology, Boston Children’s Hospital, Harvard Medical School
- Pui Y. Lee
- Division of Immunology, Boston Children’s Hospital, Harvard Medical School
- DOI
- https://doi.org/10.1038/s41467-022-34480-6
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 15
Abstract
Still’s disease is an inflammatory syndrome linked to the development of further immune dysregulation and hypercytokinaemia termed macrophage activation syndrome. Here the authors implicate the mechanistic target of rapamycin complex 1 in murine models of Still’s disease and macrophage activation syndrome, and provide associations with clinical cases in patients
