Folia Neuropathologica (Jun 2022)

WHO CNS5 2021 classification of gliomas: a practical review and road signs for diagnosing pathologists and proper patho-clinical and neuro-oncological cooperation

  • Aleksandra Sejda,
  • Wiesława Grajkowska,
  • Joanna Trubicka,
  • Ewa Szutowicz,
  • Tomasz Wojdacz,
  • Wojciech Kloc,
  • Ewa Iżycka-Świeszewska

DOI
https://doi.org/10.5114/fn.2022.118183
Journal volume & issue
Vol. 60, no. 2
pp. 137 – 152

Abstract

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The 5th edition of World Health Organization (WHO) Central Nervous System (CNS) tumours classification has transformed the pathological diagnosis of gliomas from purely histological to the multilayered integrated one with molecular biomarkers necessary for proper classification, risk stratification, and prognostic-predictive clinical purposes. Because of deep and important changes in taxonomy and diagnostic approach to gliomas, this manuscript is a review of WHO CNS classification 5th edition with general testing guidance for pathologists and clinicians working in neuro-oncology.

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