CARBOHYDRATE METABOLISM DISORDERS IN THE HEART AGEING

Abstract

The heart itself ageing is characterized by structural and functional changes, determined just by older age, even in absence of cardiovascular pathology. Carbohydrate metabolism disorders, based upon the insulin resistance, are common in elderly, and worsen the processes of ageing, including the heart. Structural changes in the heart are characterized by development of concentric remodelling of the left ventricle myocardium, and functional — by diastolic function impairment, with saved systolic function. The review focuses on the influence of ageing and carbohydrate metabolism disorders on the structure and function of myocardium, and the obvious fact is discussed, that earlier screening and correction of insulin resistance and glucose metabolism disorders might prevent or delay the progression of age-related heart failure.

Keywords

• heart ageing
• diastolic dysfunction
• diabetes type 2
• insulin resistance