Investigating in vitro Effect of Endodontic Calcium Silicate-based Biomaterials on the Human Cell Survival: A Systematic Review

Abstract

Background and purpose: The use of biomaterials in restorative dentistry is receiving increasing attention. In the treatment of living pulp, calcium silicate-based materials are used, the most common of which are MTA, biodentine, and CEM Cement. The present research aimed to conduct a systematic review to investigate the cytotoxic effect of the mentioned three types of calcium silicate-based cement. Materials and methods: In this review study, English databases, including Pubmed, Scopus, Web of Science, Cochrane, ProQuest, Wiley, and Ovid (All Database included Embase), and all the related articles worldwide from the beginning to February 16, 2023, which were published in English, were retrieved. In this context, studies that investigated the cytotoxicity of three types of calcium silicate-based cement were included. Results: Out of a total of 8,004 articles, 32 articles that met the inclusion criteria were examined. The obtained findings revealed no significant difference between the three materials. Conclusion: The review of the studies indicated that all three biomaterials (MTA, biodentine, and CEM Cement) positively and appropriately affected cell survival. Therefore, using these biomaterials in dental restoration and reconstruction treatments is recommended.

Keywords

• biodentine
• calcium silicate
• cell survival
• cem cement
• endodontic biomaterial
• mta