Hepcidin inhibits Smad3 phosphorylation in hepatic stellate cells by impeding ferroportin-mediated regulation of Akt

Chang Yeob Han; Ja Hyun Koo; Sung Hoon Kim; Sara Gardenghi; Stefano Rivella; Pavel Strnad; Se Jin Hwang; Sang Geon Kim

doi:10.1038/ncomms13817

Nature Communications (Dec 2016)

Hepcidin inhibits Smad3 phosphorylation in hepatic stellate cells by impeding ferroportin-mediated regulation of Akt

Chang Yeob Han,
Ja Hyun Koo,
Sung Hoon Kim,
Sara Gardenghi,
Stefano Rivella,
Pavel Strnad,
Se Jin Hwang,
Sang Geon Kim

Affiliations

Chang Yeob Han: College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University
Ja Hyun Koo: College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University
Sung Hoon Kim: College of Medicine, Hanyang University
Sara Gardenghi: Department of Pediatrics, Division of Hematology-Oncology, Weill Cornell Medical College
Stefano Rivella: Department of Pediatrics, Division of Hematology-Oncology, Weill Cornell Medical College
Pavel Strnad: IZKF and Department of Internal Medicine III, University Hospital Aachen
Se Jin Hwang: College of Medicine, Hanyang University
Sang Geon Kim: College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University

DOI: https://doi.org/10.1038/ncomms13817
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 14

Abstract

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The peptide hormone hepcidin is released from hepatocytes and regulates iron homoeostasis. Here, the authors show that hepcidin also regulates the activation of hepatic stellate cells (HSCs) in mouse models of liver fibrosis by reducing ferroportin expression and inhibiting the HSC response to TGFβ.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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