Histophysiological study of aluminum chloride effect on male rats

Abstract

This study was designed to detect the effects of aluminum chloride AlCl3 on some pathophysiological features of adult male rats. Eighteen rats were divided to 3 groups of 6 animals each. These included untreated control and 2 treated groups received AlCl3 at the doses 40 and 80 mg/kg of body weight, orally and daily for 30 days. The following parameters were recorded: Body weight (weekly), central nervous system activity tests (weekly), hematological examinations at 15 and 30 days of experimentally and gross and histopathology for brain, liver, kidneys and heart at the day (30). The results showed a significant decrease in body weight mean of 3rd group (80 mg/kg) at 4th week, a significant decrease in the activity associated with time progress in experiment by recording (moving onset, square crossed and rearing in 3 minutes, negative geotaxis) tests, there were no significant differences between groups at pack cell volume and hemoglobin concentration with a significant decrease in total leukocyte count at 2nd group (40 mg/kg). Differential leukocyte count revealed significant increase in lymphocyte at day 30. Histopathological changes were neuronal vaculation and proliferation of microgelial cells in brain, vacular degeneration and lymphocytic infiltrations in hepatic parenchyma with mild portal fibrosis in liver, at kidneys there were cloudy swelling, coagulative necrosis to the renal tubular epithelium, more severely noticed at 3rd group, no pathological changes were noticed at myocardium and coronary arteries at both treated groups.