Nature Communications (Jun 2018)
Cyclophilin A enables specific HIV-1 Tat palmitoylation and accumulation in uninfected cells
Abstract
It is not clear whether and how incoming HIV-1 Tat accumulates in uninfected cells. Here, Chopard et al. show that, in uninfected cells, incoming Tat is palmitoylated on Cys31 by DHHC-20, which increases its affinity for PI(4,5)P2 and results in its accumulation at the plasma membrane.
