Influenza A virus M2 protein triggers mitochondrial DNA-mediated antiviral immune responses

Miyu Moriyama; Takumi Koshiba; Takeshi Ichinohe

doi:10.1038/s41467-019-12632-5

Nature Communications (Oct 2019)

Influenza A virus M2 protein triggers mitochondrial DNA-mediated antiviral immune responses

Miyu Moriyama,
Takumi Koshiba,
Takeshi Ichinohe

Affiliations

Miyu Moriyama: Division of Viral Infection, Department of Infectious Disease Control, International Research Center for Infectious Diseases, Institute of Medical Science, The University of Tokyo
Takumi Koshiba: Department of Chemistry, Faculty of Science, Fukuoka University
Takeshi Ichinohe: Division of Viral Infection, Department of Infectious Disease Control, International Research Center for Infectious Diseases, Institute of Medical Science, The University of Tokyo

DOI: https://doi.org/10.1038/s41467-019-12632-5
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 14

Abstract

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Cytosolic mitochondrial DNA (mtDNA) plays a role in innate antiviral immunity but how this is triggered during infection remains unclear. Here, the authors provide evidence that the Influenza virus protein M2 stimulates translocation of mtDNA into the cytosol in a MAVS-dependent manner.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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