BMC Medicine (Jul 2022)
Prevalence and risk factors of post-COVID-19 condition in adults and children at 6 and 12 months after hospital discharge: a prospective, cohort study in Moscow (StopCOVID)
- Ekaterina Pazukhina,
- Margarita Andreeva,
- Ekaterina Spiridonova,
- Polina Bobkova,
- Anastasia Shikhaleva,
- Yasmin El-Taravi,
- Mikhail Rumyantsev,
- Aysylu Gamirova,
- Anastasiia Bairashevskaia,
- Polina Petrova,
- Dina Baimukhambetova,
- Maria Pikuza,
- Elina Abdeeva,
- Yulia Filippova,
- Salima Deunezhewa,
- Nikita Nekliudov,
- Polina Bugaeva,
- Nikolay Bulanov,
- Sergey Avdeev,
- Valentina Kapustina,
- Alla Guekht,
- Audrey DunnGalvin,
- Pasquale Comberiati,
- Diego G. Peroni,
- Christian Apfelbacher,
- Jon Genuneit,
- Luis Felipe Reyes,
- Caroline L. H. Brackel,
- Victor Fomin,
- Andrey A. Svistunov,
- Peter Timashev,
- Lyudmila Mazankova,
- Alexandra Miroshina,
- Elmira Samitova,
- Svetlana Borzakova,
- Elena Bondarenko,
- Anatoliy A. Korsunskiy,
- Gail Carson,
- Louise Sigfrid,
- Janet T. Scott,
- Matthew Greenhawt,
- Danilo Buonsenso,
- Malcolm G. Semple,
- John O. Warner,
- Piero Olliaro,
- Dale M. Needham,
- Petr Glybochko,
- Denis Butnaru,
- Ismail M. Osmanov,
- Daniel Munblit,
- Sechenov StopCOVID Research Team
Affiliations
- Ekaterina Pazukhina
- Laboratory of Health Economics, Institute of Applied Economic Studies, The Russian Presidential Academy of National Economy and Public Administration
- Margarita Andreeva
- Department of Paediatrics and Paediatric Infectious Diseases, Institute of Child’s Health, Sechenov First Moscow State Medical University (Sechenov University)
- Ekaterina Spiridonova
- Department of Paediatrics and Paediatric Infectious Diseases, Institute of Child’s Health, Sechenov First Moscow State Medical University (Sechenov University)
- Polina Bobkova
- Department of Paediatrics and Paediatric Infectious Diseases, Institute of Child’s Health, Sechenov First Moscow State Medical University (Sechenov University)
- Anastasia Shikhaleva
- Department of Paediatrics and Paediatric Infectious Diseases, Institute of Child’s Health, Sechenov First Moscow State Medical University (Sechenov University)
- Yasmin El-Taravi
- Department of Paediatrics and Paediatric Infectious Diseases, Institute of Child’s Health, Sechenov First Moscow State Medical University (Sechenov University)
- Mikhail Rumyantsev
- Department of Paediatrics and Paediatric Infectious Diseases, Institute of Child’s Health, Sechenov First Moscow State Medical University (Sechenov University)
- Aysylu Gamirova
- Department of Paediatrics and Paediatric Infectious Diseases, Institute of Child’s Health, Sechenov First Moscow State Medical University (Sechenov University)
- Anastasiia Bairashevskaia
- Department of Paediatrics and Paediatric Infectious Diseases, Institute of Child’s Health, Sechenov First Moscow State Medical University (Sechenov University)
- Polina Petrova
- Department of Paediatrics and Paediatric Infectious Diseases, Institute of Child’s Health, Sechenov First Moscow State Medical University (Sechenov University)
- Dina Baimukhambetova
- Department of Paediatrics and Paediatric Infectious Diseases, Institute of Child’s Health, Sechenov First Moscow State Medical University (Sechenov University)
- Maria Pikuza
- Department of Paediatrics and Paediatric Infectious Diseases, Institute of Child’s Health, Sechenov First Moscow State Medical University (Sechenov University)
- Elina Abdeeva
- Department of Paediatrics and Paediatric Infectious Diseases, Institute of Child’s Health, Sechenov First Moscow State Medical University (Sechenov University)
- Yulia Filippova
- Department of Paediatrics and Paediatric Infectious Diseases, Institute of Child’s Health, Sechenov First Moscow State Medical University (Sechenov University)
- Salima Deunezhewa
- Department of Paediatrics and Paediatric Infectious Diseases, Institute of Child’s Health, Sechenov First Moscow State Medical University (Sechenov University)
- Nikita Nekliudov
- Department of Paediatrics and Paediatric Infectious Diseases, Institute of Child’s Health, Sechenov First Moscow State Medical University (Sechenov University)
- Polina Bugaeva
- Department of Paediatrics and Paediatric Infectious Diseases, Institute of Child’s Health, Sechenov First Moscow State Medical University (Sechenov University)
- Nikolay Bulanov
- Tareev Clinic of Internal Diseases, Sechenov First Moscow State Medical University (Sechenov University)
- Sergey Avdeev
- Clinic of Pulmonology, Sechenov First Moscow State Medical University (Sechenov University)
- Valentina Kapustina
- Department of Internal Medicine №1, Institute of Clinical Medicine, Sechenov First Moscow State Medical University (Sechenov University)
- Alla Guekht
- Research and Clinical Center for Neuropsychiatry
- Audrey DunnGalvin
- Department of Paediatrics and Paediatric Infectious Diseases, Institute of Child’s Health, Sechenov First Moscow State Medical University (Sechenov University)
- Pasquale Comberiati
- Department of Clinical and Experimental Medicine, Section of Pediatrics, University of Pisa
- Diego G. Peroni
- Department of Clinical and Experimental Medicine, Section of Pediatrics, University of Pisa
- Christian Apfelbacher
- Institute of Social Medicine and Health Systems Research, Faculty of Medicine, Otto von Guericke University Magdeburg
- Jon Genuneit
- Pediatric Epidemiology, Department of Pediatrics, Medical Faculty, Leipzig University
- Luis Felipe Reyes
- Universidad de La Sabana
- Caroline L. H. Brackel
- Department of Pediatric Pulmonology, Emma Children’s Hospital, Amsterdam University Medical Centers
- Victor Fomin
- Sechenov First Moscow State Medical University (Sechenov University)
- Andrey A. Svistunov
- Sechenov First Moscow State Medical University (Sechenov University)
- Peter Timashev
- Institute for Regenerative Medicine, Sechenov First Moscow State Medical University (Sechenov University)
- Lyudmila Mazankova
- Russian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of the Russian Federation
- Alexandra Miroshina
- ZA Bashlyaeva Children’s Municipal Clinical Hospital
- Elmira Samitova
- Russian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of the Russian Federation
- Svetlana Borzakova
- Pirogov Russian National Research Medical University
- Elena Bondarenko
- Department of Paediatrics and Paediatric Infectious Diseases, Institute of Child’s Health, Sechenov First Moscow State Medical University (Sechenov University)
- Anatoliy A. Korsunskiy
- Department of Paediatrics and Paediatric Infectious Diseases, Institute of Child’s Health, Sechenov First Moscow State Medical University (Sechenov University)
- Gail Carson
- Nuffield Department of Medicine, ISARIC Global Support Centre, University of Oxford
- Louise Sigfrid
- Nuffield Department of Medicine, ISARIC Global Support Centre, University of Oxford
- Janet T. Scott
- MRC-University of Glasgow Centre for Virus Research
- Matthew Greenhawt
- Department of Pediatrics, Section of Allergy/Immunology, Children’s Hospital Colorado, University of Colorado School of Medicine
- Danilo Buonsenso
- Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS
- Malcolm G. Semple
- Health Protection Research Unit in Emerging and Zoonotic Infections, Institute of Infection, Veterinary and Ecological Sciences, Faculty of Health and Life Sciences, University of Liverpool
- John O. Warner
- Inflammation, Repair and Development Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College London
- Piero Olliaro
- Nuffield Department of Medicine, ISARIC Global Support Centre, University of Oxford
- Dale M. Needham
- Outcomes After Critical Illness and Surgery (OACIS) Research Group, Johns Hopkins University
- Petr Glybochko
- Sechenov First Moscow State Medical University (Sechenov University)
- Denis Butnaru
- Sechenov First Moscow State Medical University (Sechenov University)
- Ismail M. Osmanov
- Pirogov Russian National Research Medical University
- Daniel Munblit
- Department of Paediatrics and Paediatric Infectious Diseases, Institute of Child’s Health, Sechenov First Moscow State Medical University (Sechenov University)
- Sechenov StopCOVID Research Team
- DOI
- https://doi.org/10.1186/s12916-022-02448-4
- Journal volume & issue
-
Vol. 20,
no. 1
pp. 1 – 12
Abstract
Abstract Background Previous studies assessing the prevalence of COVID-19 sequelae in adults and children were performed in the absence of an agreed definition. We investigated prevalence of post-COVID-19 condition (PCC) (WHO definition), at 6- and 12-months follow-up, amongst previously hospitalised adults and children and assessed risk factors. Methods Prospective cohort study of children and adults with confirmed COVID-19 in Moscow, hospitalised between April and August, 2020. Two follow-up telephone interviews, using the International Severe Acute Respiratory and Emerging Infection Consortium survey, were performed at 6 and 12 months after discharge. Results One thousand thirteen of 2509 (40%) of adults and 360 of 849 (42%) of children discharged participated in both the 6- and 12-month follow-ups. PCC prevalence was 50% (95% CI 47–53) in adults and 20% (95% CI 16–24) in children at 6 months, with decline to 34% (95% CI 31–37) and 11% (95% CI 8–14), respectively, at 12 months. In adults, female sex was associated with PCC at 6- and 12-month follow-up (OR 2.04, 95% CI 1.57 to 2.65) and (OR 2.04, 1.54 to 2.69), respectively. Pre-existing hypertension (OR 1.42, 1.04 to 1.94) was associated with post-COVID-19 condition at 12 months. In children, neurological comorbidities were associated with PCC both at 6 months (OR 4.38, 1.36 to 15.67) and 12 months (OR 8.96, 2.55 to 34.82) while allergic respiratory diseases were associated at 12 months (OR 2.66, 1.04 to 6.47). Conclusions Although prevalence of PCC declined one year after discharge, one in three adults and one in ten children experienced ongoing sequelae. In adults, females and persons with pre-existing hypertension, and in children, persons with neurological comorbidities or allergic respiratory diseases are at higher risk of PCC.
Keywords
