Dataset on sociability, cognitive function, gene and protein expression of molecules involved in social behavior, reward system and synapse function following early-life status epilepticus in Wistar rats
Ana Miriã Pacífico,
Samuel P. Batista,
Fernanda T. Ribeiro,
Pedro B. dos Santos,
Gabriel Bruno Silveira,
Bruna Pascarelli Pedrico do Nascimento,
Eduardo Dias Junior,
Geraldo Henrique L. Barbosa,
Miriam Oliveira Ribeiro,
Sergio Gomes da Silva,
Roberta M. Cysneiros
Affiliations
Ana Miriã Pacífico
Developmental Disabilities Graduate Program. Mackenzie Presbyterian University, São Paulo, Brazil. Rua da Consolação, 930. Prédio 28, CEP 01302-907 São Paulo, SP, Brazil
Samuel P. Batista
Developmental Disabilities Graduate Program. Mackenzie Presbyterian University, São Paulo, Brazil. Rua da Consolação, 930. Prédio 28, CEP 01302-907 São Paulo, SP, Brazil
Fernanda T. Ribeiro
Developmental Disabilities Graduate Program. Mackenzie Presbyterian University, São Paulo, Brazil. Rua da Consolação, 930. Prédio 28, CEP 01302-907 São Paulo, SP, Brazil
Pedro B. dos Santos
Developmental Disabilities Graduate Program. Mackenzie Presbyterian University, São Paulo, Brazil. Rua da Consolação, 930. Prédio 28, CEP 01302-907 São Paulo, SP, Brazil
Gabriel Bruno Silveira
Developmental Disabilities Graduate Program. Mackenzie Presbyterian University, São Paulo, Brazil. Rua da Consolação, 930. Prédio 28, CEP 01302-907 São Paulo, SP, Brazil
Bruna Pascarelli Pedrico do Nascimento
Developmental Disabilities Graduate Program. Mackenzie Presbyterian University, São Paulo, Brazil. Rua da Consolação, 930. Prédio 28, CEP 01302-907 São Paulo, SP, Brazil
Eduardo Dias Junior
Developmental Disabilities Graduate Program. Mackenzie Presbyterian University, São Paulo, Brazil. Rua da Consolação, 930. Prédio 28, CEP 01302-907 São Paulo, SP, Brazil
Geraldo Henrique L. Barbosa
Developmental Disabilities Graduate Program. Mackenzie Presbyterian University, São Paulo, Brazil. Rua da Consolação, 930. Prédio 28, CEP 01302-907 São Paulo, SP, Brazil
Miriam Oliveira Ribeiro
Developmental Disabilities Graduate Program. Mackenzie Presbyterian University, São Paulo, Brazil. Rua da Consolação, 930. Prédio 28, CEP 01302-907 São Paulo, SP, Brazil
Sergio Gomes da Silva
Hospital do Câncer de Muriaé - Fundação Cristiano Varella, Muriaé, Brazil; Centro Universitário UNIFAMINAS, Muriaé, Brazil
Roberta M. Cysneiros
Developmental Disabilities Graduate Program. Mackenzie Presbyterian University, São Paulo, Brazil. Rua da Consolação, 930. Prédio 28, CEP 01302-907 São Paulo, SP, Brazil; Corresponding author.
Early-life status epilepticus produces deficit in social interaction and vocalization, enhances anxiety, no cognitive impairment and alters functional connectivity within the hippocampus (CA3-CA1) and between the hippocampus and prefrontal cortex [1–12], but the underlying mechanisms remain unknown. This data article contains behavioral and molecular data of the adult male Wistar rats subjected to early life pilocarpine-induced seizures. Animal's behaviors were assessed to social memory and social motivation, working and reference memories and cognitive flexibility. The brain tissues (hypothalamus, hippocampus, amygdala, and striatum) were probed to gene and protein expression of molecules related to social behavior, reward system and synaptic function.
