THE ROLE OF INFLAMMATORY MEDIATORS AND TOLL-LIKE RECEPTORS IN NEWBORN BABIES WITH RESPIRATORY DISORDERS, WHO RECEIVE ARTIFICIAL LUNG VENTILATION

Abstract

Purpose: To study the role of pro-inflammatory and anti-inflammatory cytokines, Toll-like receptors in the pathogenesis of respiratory disorders in full-term newborns.Materials and methods. The programme of examination included the determination of production of IL-1β, IL-6, IL-8, TNF-α, TGF-β1 and RANTES in bronchoalveolar lavage and blood serum as well as expression of Toll-like receptors on monocytes of peripheral blood in newborn babies with respiratory disorders. Cytokines in the bronchoalveolar lavage, blood serum and expression of Toll-like receptors on the monocytes of peripheral blood were determined in 36 full-term newborns.Results. The study showed peculiarities of a cytokine profile. In case of respiratory disorders caused by meconium aspiration syndrome (MAS) and respiratory distress syndrome (RDS) high levels of IL-1β, IL-6, IL-8 and TNF–α were revealed in the blood serum and the bronchoalveolar lavage. In the peripheral blood of the newborns with respiratory disorders there was reduced expression of TLR-2 (CD14+CD282+) and TLR-4 (CD14+CD284+).Summary. The received data indicate an important role of the mechanisms of local protection and inborn immunity in the course and the outcome of respiratory disorders in newborn babies.

Keywords

• newborn babies
• mas
• rds
• pro-inflammatory and anti-inflammatory cytokines