Coactivator-associated arginine methyltransferase 1: A versatile player in cell differentiation and development

Zhongrui Ma; Xinxing Lyu; Ning Qin; Haoyu Liu; Mengrui Zhang; Yongchao Lai; Bo Dong; Peiyuan Lu

Genes and Diseases (Nov 2023)

Coactivator-associated arginine methyltransferase 1: A versatile player in cell differentiation and development

Zhongrui Ma,
Xinxing Lyu,
Ning Qin,
Haoyu Liu,
Mengrui Zhang,
Yongchao Lai,
Bo Dong,
Peiyuan Lu

Affiliations

Zhongrui Ma: Medical Research Center, The First Affiliated Hospital of Shandong First Medical University, Jinan, Shandong 250014, China; Department of Immunology, Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong 250117, China
Xinxing Lyu: Medical Research Center, The First Affiliated Hospital of Shandong First Medical University, Jinan, Shandong 250014, China; Department of Biochemistry and Molecular Biology, School of Basic Medicine, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong 250117, China
Ning Qin: Department of Biochemistry and Molecular Biology, School of Basic Medicine, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong 250117, China
Haoyu Liu: Department of Biochemistry and Molecular Biology, School of Basic Medicine, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong 250117, China
Mengrui Zhang: Department of Biochemistry and Molecular Biology, School of Basic Medicine, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong 250117, China
Yongchao Lai: Medical Research Center, The First Affiliated Hospital of Shandong First Medical University, Jinan, Shandong 250014, China
Bo Dong: Department of Cardiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250021, China
Peiyuan Lu: Medical Research Center, The First Affiliated Hospital of Shandong First Medical University, Jinan, Shandong 250014, China; Department of Immunology, Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong 250117, China; Department of Biochemistry and Molecular Biology, School of Basic Medicine, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong 250117, China; Corresponding author. Medical Research Center, the First Affiliated Hospital of Shandong First Medical University, Jinan, Shandong 250014, China.

Journal volume & issue: Vol. 10, no. 6
pp. 2383 – 2392

Abstract

Read online

Protein arginine methylation is a common post-translational modification involved in the regulation of various cellular functions. Coactivator-associated arginine methyltransferase 1 (CARM1) is a protein arginine methyltransferase that asymmetrically dimethylates histone H3 and non-histone proteins to regulate gene transcription. CARM1 has been found to play important roles in cell differentiation and development, cell cycle progression, autophagy, metabolism, pre-mRNA splicing and transportation, and DNA replication. In this review, we describe the molecular characteristics of CARM1 and summarize its roles in the regulation of cell differentiation and development in mammals.

Published in Genes and Diseases

ISSN: 2352-3042 (Online)
Publisher: KeAi Communications Co., Ltd.
Country of publisher: China
LCC subjects: Medicine: Medicine (General); Science: Biology (General): Genetics
Website: https://www.keaipublishing.com/en/journals/genes-and-diseases/

About the journal

Abstract

Keywords