Nature Communications (Jun 2017)

Extra-embryonic tissue spreading directs early embryo morphogenesis in killifish

  • Germán Reig,
  • Mauricio Cerda,
  • Néstor Sepúlveda,
  • Daniela Flores,
  • Victor Castañeda,
  • Masazumi Tada,
  • Steffen Härtel,
  • Miguel L. Concha

DOI
https://doi.org/10.1038/ncomms15431
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 14

Abstract

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The role of mechanical signals in early development are not fully understood. Here, the authors use the simplicity of early killifish embryos to show that tension arising from extra-embryonic epithelial expansion directs the spreading of mesenchymal-like embryonic cells during early morphogenesis.