Role of Endocrine Function of Adipose Tissue in the Development of Chronic Obstructive Pulmonary Disease: a Review of Recent Advances

Abstract

In addition to affecting adjacent tissues and organs through its mechanical characteristics or mechanical functions, adipose tissue participates in the development of a variety of obesity-related diseases by effectively establishing an interaction information network with organs of the respiratory system and other remote organs through signaling pathways of adipokines secreted by adipocytes. As a breakthrough in the field of endocrinology, the endocrine function of adipose tissue has attracted increasing attention in life sciences. A number of recent epidemiological studies have revealed that obesity is an important risk factor for chronic obstructive pulmonary disease and other respiratory impairments. We reviewed recent advances in the role of adiponectin, leptin, endolipin and other adipocytokines in the development of COPD, providing new ideas for the prevention and treatment of COPD from the perspective of endocrine function of adipose tissue.

Keywords

• pulmonary disease, chronic obstructive|obesity|adipose tissue|endocrine function|mechanism research