Arterial Hypertension (Jun 2025)
The association of clinical and biochemical indicators with the rate of aging in patients with arterial hypertension during wartime
Abstract
BACKGROUND: Our study aimed to assess changes in the levels of clinical and biochemical parameters, as well as aging markers in blood, over different treatment periods in arterial hypertension (HTN) patients during wartime, and to compare the obtained results with changes in the aging rate of these patients. MATERIAL AND METHODS: Seventy-eight HTN patients with a median age of 51.9 years were examined twice and divided into groups: in group 1 the follow-up visit was before 27 weeks (n = 38), and in group 2 the follow-up visit was within 27–57.3 weeks (n = 40). Phenotypic age (PA) was determined using the method of Levine M. E. et al. (2018) to evaluate the aging rate. Additional markers of aging included C-reactive protein (CRP), 8-hydroxy-2’-deoxyguanosine (8-OhdG), sirtuin 1 (SIRT1), and telomere length in the blood. RESULTS: Between visits, waist circumference decreased only in group 1; changes in lymphocyte levels, red cell distribution width, levels of total cholesterol, triglycerides, uric acid, and albumin were found only in group 2. The prevalence of premature aging among HTN patients decreased from 75% to 55%. Weight was found to be inversely related to SIRT1 levels, while BMI was directly related to 8-OHdG levels. An association between the accelerated aging rates during follow-up and the development of an unfavorable anthropometric profile, lipid profile changes, and pro-inflammatory state development was found. CONCLUSIONS: In wartime, most patients with HTN exhibit accelerated aging, linked to worsening anthropometric and clinical-biochemical indicators. Biannual screening for its detection is needed. SIRT1 and 8-OHdG offer additional insights into aging rates in HTN patients.
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