Nature Communications (Sep 2018)
Microbiota-derived short-chain fatty acids promote Th1 cell IL-10 production to maintain intestinal homeostasis
- Mingming Sun,
- Wei Wu,
- Liang Chen,
- Wenjing Yang,
- Xiangsheng Huang,
- Caiyun Ma,
- Feidi Chen,
- Yi Xiao,
- Ye Zhao,
- Chunyan Ma,
- Suxia Yao,
- Victor H. Carpio,
- Sara M. Dann,
- Qihong Zhao,
- Zhanju Liu,
- Yingzi Cong
Affiliations
- Mingming Sun
- Department of Gastroenterology, The Shanghai Tenth Peoples Hospital, Tongji University
- Wei Wu
- Department of Gastroenterology, The Shanghai Tenth Peoples Hospital, Tongji University
- Liang Chen
- Department of Gastroenterology, The Shanghai Tenth Peoples Hospital, Tongji University
- Wenjing Yang
- Department of Gastroenterology, The Shanghai Tenth Peoples Hospital, Tongji University
- Xiangsheng Huang
- Department of Microbiology and Immunology, The University of Texas Medical Branch
- Caiyun Ma
- Department of Gastroenterology, The Shanghai Tenth Peoples Hospital, Tongji University
- Feidi Chen
- Department of Pathology, University of Texas Medical Branch
- Yi Xiao
- Department of Microbiology and Immunology, The University of Texas Medical Branch
- Ye Zhao
- Department of Microbiology and Immunology, The University of Texas Medical Branch
- Chunyan Ma
- Department of Microbiology and Immunology, The University of Texas Medical Branch
- Suxia Yao
- Department of Microbiology and Immunology, The University of Texas Medical Branch
- Victor H. Carpio
- Department of Internal Medicine, The University of Texas Medical Branch
- Sara M. Dann
- Department of Internal Medicine, The University of Texas Medical Branch
- Qihong Zhao
- Bristol-Myers Squibb
- Zhanju Liu
- Department of Gastroenterology, The Shanghai Tenth Peoples Hospital, Tongji University
- Yingzi Cong
- Department of Microbiology and Immunology, The University of Texas Medical Branch
- DOI
- https://doi.org/10.1038/s41467-018-05901-2
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 15
Abstract
T cells play a critical role in intestinal homeostasis, with increasing evidence suggesting a role for the microbiome metabolome in modulating this response. Here the authors show short-chain fatty acids promote IL-10 production in Th1 cells.
