Independent control of the thermodynamic and kinetic properties of aptamer switches

Brandon D. Wilson; Amani A. Hariri; Ian A. P. Thompson; Michael Eisenstein; H. Tom Soh

doi:10.1038/s41467-019-13137-x

Nature Communications (Nov 2019)

Independent control of the thermodynamic and kinetic properties of aptamer switches

Brandon D. Wilson,
Amani A. Hariri,
Ian A. P. Thompson,
Michael Eisenstein,
H. Tom Soh

Affiliations

Brandon D. Wilson: Department of Chemical Engineering, Stanford University
Amani A. Hariri: Department of Electrical Engineering, Stanford University
Ian A. P. Thompson: Department of Electrical Engineering, Stanford University
Michael Eisenstein: Department of Electrical Engineering, Stanford University
H. Tom Soh: Department of Electrical Engineering, Stanford University

DOI: https://doi.org/10.1038/s41467-019-13137-x
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 9

Abstract

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Aptamer switches are promising biotechnological tools but coupling of their affinity and temporal response limits their versatility. Here, the authors developed an intramolecular strand-displacement strategy that allows for independent fine-tuning of thermodynamics and kinetics of aptamer switches.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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