Nature Communications (Sep 2019)
Zika virus replicates in adult human brain tissue and impairs synapses and memory in mice
- Claudia P. Figueiredo,
- Fernanda G. Q. Barros-Aragão,
- Rômulo L. S. Neris,
- Paula S. Frost,
- Carolina Soares,
- Isis N. O. Souza,
- Julianna D. Zeidler,
- Daniele C. Zamberlan,
- Virginia L. de Sousa,
- Amanda S. Souza,
- André Luis A. Guimarães,
- Maria Bellio,
- Jorge Marcondes de Souza,
- Soniza V. Alves-Leon,
- Gilda A. Neves,
- Heitor A. Paula-Neto,
- Newton G. Castro,
- Fernanda G. De Felice,
- Iranaia Assunção-Miranda,
- Julia R. Clarke,
- Andrea T. Da Poian,
- Sergio T. Ferreira
Affiliations
- Claudia P. Figueiredo
- School of Pharmacy, Federal University of Rio de Janeiro
- Fernanda G. Q. Barros-Aragão
- School of Pharmacy, Federal University of Rio de Janeiro
- Rômulo L. S. Neris
- Institute of Microbiology Paulo de Goes, Federal University of Rio de Janeiro
- Paula S. Frost
- School of Pharmacy, Federal University of Rio de Janeiro
- Carolina Soares
- School of Pharmacy, Federal University of Rio de Janeiro
- Isis N. O. Souza
- School of Pharmacy, Federal University of Rio de Janeiro
- Julianna D. Zeidler
- Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro
- Daniele C. Zamberlan
- School of Pharmacy, Federal University of Rio de Janeiro
- Virginia L. de Sousa
- School of Pharmacy, Federal University of Rio de Janeiro
- Amanda S. Souza
- Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro
- André Luis A. Guimarães
- School of Pharmacy, Federal University of Rio de Janeiro
- Maria Bellio
- Institute of Microbiology Paulo de Goes, Federal University of Rio de Janeiro
- Jorge Marcondes de Souza
- Division of Neurosurgery and Division of Neurology/Epilepsy Program, Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro
- Soniza V. Alves-Leon
- Division of Neurosurgery and Division of Neurology/Epilepsy Program, Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro
- Gilda A. Neves
- Institute of Biomedical Sciences, Federal University of Rio de Janeiro
- Heitor A. Paula-Neto
- School of Pharmacy, Federal University of Rio de Janeiro
- Newton G. Castro
- Institute of Biomedical Sciences, Federal University of Rio de Janeiro
- Fernanda G. De Felice
- Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro
- Iranaia Assunção-Miranda
- Institute of Microbiology Paulo de Goes, Federal University of Rio de Janeiro
- Julia R. Clarke
- School of Pharmacy, Federal University of Rio de Janeiro
- Andrea T. Da Poian
- Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro
- Sergio T. Ferreira
- Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro
- DOI
- https://doi.org/10.1038/s41467-019-11866-7
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 16
Abstract
Here, using ex-vivo human adult cortical tissue and a mouse model, the authors investigate the functional consequences of Zika virus (ZIKV) infection in the adult brain, and show that ZIKV causes synapse damage and altered brain function that impacts cognition via activation of innate and inflammatory factors.
