Nature Communications (Sep 2021)

ECNet is an evolutionary context-integrated deep learning framework for protein engineering

  • Yunan Luo,
  • Guangde Jiang,
  • Tianhao Yu,
  • Yang Liu,
  • Lam Vo,
  • Hantian Ding,
  • Yufeng Su,
  • Wesley Wei Qian,
  • Huimin Zhao,
  • Jian Peng

DOI
https://doi.org/10.1038/s41467-021-25976-8
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 14

Abstract

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Protein engineering is an active area of research in which machine learning has proven quite powerful. Here, the authors present a deep learning method that integrates both general and protein-specific sequence representations to improve the engineering of one’s protein of interest.