European Radiology Experimental (Nov 2022)
NAVIGATOR: an Italian regional imaging biobank to promote precision medicine for oncologic patients
- Rita Borgheresi,
- Andrea Barucci,
- Sara Colantonio,
- Gayane Aghakhanyan,
- Massimiliano Assante,
- Elena Bertelli,
- Emanuele Carlini,
- Roberto Carpi,
- Claudia Caudai,
- Diletta Cavallero,
- Dania Cioni,
- Roberto Cirillo,
- Valentina Colcelli,
- Andrea Dell’Amico,
- Domnico Di Gangi,
- Paola Anna Erba,
- Lorenzo Faggioni,
- Zeno Falaschi,
- Michela Gabelloni,
- Rosa Gini,
- Lucio Lelii,
- Pietro Liò,
- Antonio Lorito,
- Silvia Lucarini,
- Paolo Manghi,
- Francesco Mangiacrapa,
- Chiara Marzi,
- Maria Antonietta Mazzei,
- Laura Mercatelli,
- Antonella Mirabile,
- Francesco Mungai,
- Vittorio Miele,
- Maristella Olmastroni,
- Pasquale Pagano,
- Fabiola Paiar,
- Giancarlo Panichi,
- Maria Antonietta Pascali,
- Filippo Pasquinelli,
- Jorge Eduardo Shortrede,
- Lorenzo Tumminello,
- Luca Volterrani,
- Emanuele Neri,
- on behalf of the NAVIGATOR Consortium Group
Affiliations
- Rita Borgheresi
- Academic Radiology, Department of Translational Research and of New Surgical and Medical Technology, University of Pisa
- Andrea Barucci
- “Nello Carrara” Institute of Applied Physics — IFAC of the National Research Council — CNR
- Sara Colantonio
- Institute of Information Science and Technologies — ISTI of the National Research Council — CNR
- Gayane Aghakhanyan
- Academic Radiology, Department of Translational Research and of New Surgical and Medical Technology, University of Pisa
- Massimiliano Assante
- Institute of Information Science and Technologies — ISTI of the National Research Council — CNR
- Elena Bertelli
- Department of Radiology, Careggi University Hospital
- Emanuele Carlini
- Institute of Information Science and Technologies — ISTI of the National Research Council — CNR
- Roberto Carpi
- Azienda USL Toscana Centro
- Claudia Caudai
- Institute of Information Science and Technologies — ISTI of the National Research Council — CNR
- Diletta Cavallero
- Academic Radiology, Department of Translational Research and of New Surgical and Medical Technology, University of Pisa
- Dania Cioni
- Academic Radiology, Department of Translational Research and of New Surgical and Medical Technology, University of Pisa
- Roberto Cirillo
- Institute of Information Science and Technologies — ISTI of the National Research Council — CNR
- Valentina Colcelli
- “Nello Carrara” Institute of Applied Physics — IFAC of the National Research Council — CNR
- Andrea Dell’Amico
- Institute of Information Science and Technologies — ISTI of the National Research Council — CNR
- Domnico Di Gangi
- Institute of Information Science and Technologies — ISTI of the National Research Council — CNR
- Paola Anna Erba
- Academic Radiology, Department of Translational Research and of New Surgical and Medical Technology, University of Pisa
- Lorenzo Faggioni
- Academic Radiology, Department of Translational Research and of New Surgical and Medical Technology, University of Pisa
- Zeno Falaschi
- Academic Radiology, Department of Translational Research and of New Surgical and Medical Technology, University of Pisa
- Michela Gabelloni
- Academic Radiology, Department of Translational Research and of New Surgical and Medical Technology, University of Pisa
- Rosa Gini
- Azienda Regionale di Sanità
- Lucio Lelii
- Institute of Information Science and Technologies — ISTI of the National Research Council — CNR
- Pietro Liò
- Department of Computer Science and Technology of the University of Cambridge
- Antonio Lorito
- “Nello Carrara” Institute of Applied Physics — IFAC of the National Research Council — CNR
- Silvia Lucarini
- Department of Radiology, Careggi University Hospital
- Paolo Manghi
- Institute of Information Science and Technologies — ISTI of the National Research Council — CNR
- Francesco Mangiacrapa
- Institute of Information Science and Technologies — ISTI of the National Research Council — CNR
- Chiara Marzi
- “Nello Carrara” Institute of Applied Physics — IFAC of the National Research Council — CNR
- Maria Antonietta Mazzei
- Unit of Diagnostic Imaging, Department of Medical, Surgical and Neurosciences and of Radiological Sciences, University of Siena, Azienda Ospedaliero-Universitaria Senese
- Laura Mercatelli
- Department of Radiology, Careggi University Hospital
- Antonella Mirabile
- “Nello Carrara” Institute of Applied Physics — IFAC of the National Research Council — CNR
- Francesco Mungai
- Department of Radiology, Careggi University Hospital
- Vittorio Miele
- Department of Radiology, Careggi University Hospital
- Maristella Olmastroni
- Azienda USL Toscana Centro
- Pasquale Pagano
- Institute of Information Science and Technologies — ISTI of the National Research Council — CNR
- Fabiola Paiar
- Academic Radiology, Department of Translational Research and of New Surgical and Medical Technology, University of Pisa
- Giancarlo Panichi
- Institute of Information Science and Technologies — ISTI of the National Research Council — CNR
- Maria Antonietta Pascali
- Institute of Information Science and Technologies — ISTI of the National Research Council — CNR
- Filippo Pasquinelli
- Azienda USL Toscana Centro
- Jorge Eduardo Shortrede
- Academic Radiology, Department of Translational Research and of New Surgical and Medical Technology, University of Pisa
- Lorenzo Tumminello
- Academic Radiology, Department of Translational Research and of New Surgical and Medical Technology, University of Pisa
- Luca Volterrani
- Unit of Diagnostic Imaging, Department of Medical, Surgical and Neurosciences and of Radiological Sciences, University of Siena, Azienda Ospedaliero-Universitaria Senese
- Emanuele Neri
- Academic Radiology, Department of Translational Research and of New Surgical and Medical Technology, University of Pisa
- on behalf of the NAVIGATOR Consortium Group
- DOI
- https://doi.org/10.1186/s41747-022-00306-9
- Journal volume & issue
-
Vol. 6,
no. 1
pp. 1 – 13
Abstract
Abstract NAVIGATOR is an Italian regional project boosting precision medicine in oncology with the aim of making it more predictive, preventive, and personalised by advancing translational research based on quantitative imaging and integrative omics analyses. The project’s goal is to develop an open imaging biobank for the collection and preservation of a large amount of standardised imaging multimodal datasets, including computed tomography, magnetic resonance imaging, and positron emission tomography data, together with the corresponding patient-related and omics-related relevant information extracted from regional healthcare services using an adapted privacy-preserving model. The project is based on an open-source imaging biobank and an open-science oriented virtual research environment (VRE). Available integrative omics and multi-imaging data of three use cases (prostate cancer, rectal cancer, and gastric cancer) will be collected. All data confined in NAVIGATOR (i.e., standard and novel imaging biomarkers, non-imaging data, health agency data) will be used to create a digital patient model, to support the reliable prediction of the disease phenotype and risk stratification. The VRE that relies on a well-established infrastructure, called D4Science.org, will further provide a multiset infrastructure for processing the integrative omics data, extracting specific radiomic signatures, and for identification and testing of novel imaging biomarkers through big data analytics and artificial intelligence.
Keywords
