Nature Communications (Mar 2022)
Autoantibodies targeting GPCRs and RAS-related molecules associate with COVID-19 severity
- Otavio Cabral-Marques,
- Gilad Halpert,
- Lena F. Schimke,
- Yuri Ostrinski,
- Aristo Vojdani,
- Gabriela Crispim Baiocchi,
- Paula Paccielli Freire,
- Igor Salerno Filgueiras,
- Israel Zyskind,
- Miriam T. Lattin,
- Florian Tran,
- Stefan Schreiber,
- Alexandre H. C. Marques,
- Desirée Rodrigues Plaça,
- Dennyson Leandro M. Fonseca,
- Jens Y. Humrich,
- Antje Müller,
- Lasse M. Giil,
- Hanna Graßhoff,
- Anja Schumann,
- Alexander Hackel,
- Juliane Junker,
- Carlotta Meyer,
- Hans D. Ochs,
- Yael Bublil Lavi,
- Carmen Scheibenbogen,
- Ralf Dechend,
- Igor Jurisica,
- Kai Schulze-Forster,
- Jonathan I. Silverberg,
- Howard Amital,
- Jason Zimmerman,
- Harry Heidecke,
- Avi Z. Rosenberg,
- Gabriela Riemekasten,
- Yehuda Shoenfeld
Affiliations
- Otavio Cabral-Marques
- Department of Immunology, Institute of Biomedical Sciences, University of São Paulo
- Gilad Halpert
- Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center
- Lena F. Schimke
- Department of Immunology, Institute of Biomedical Sciences, University of São Paulo
- Yuri Ostrinski
- Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center
- Aristo Vojdani
- Department of Immunology, Immunosciences Laboratory, Inc.
- Gabriela Crispim Baiocchi
- Department of Immunology, Institute of Biomedical Sciences, University of São Paulo
- Paula Paccielli Freire
- Department of Immunology, Institute of Biomedical Sciences, University of São Paulo
- Igor Salerno Filgueiras
- Department of Immunology, Institute of Biomedical Sciences, University of São Paulo
- Israel Zyskind
- Department of Pediatrics, NYU Langone Medical Center
- Miriam T. Lattin
- Department of Biology, Yeshiva University
- Florian Tran
- Department of Internal Medicine I, University Medical Center Schleswig-Holstein Campus Kiel
- Stefan Schreiber
- Department of Internal Medicine I, University Medical Center Schleswig-Holstein Campus Kiel
- Alexandre H. C. Marques
- Department of Immunology, Institute of Biomedical Sciences, University of São Paulo
- Desirée Rodrigues Plaça
- Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo
- Dennyson Leandro M. Fonseca
- Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo
- Jens Y. Humrich
- Department of Rheumatology, University Medical Center Schleswig-Holstein Campus Lübeck
- Antje Müller
- Department of Rheumatology, University Medical Center Schleswig-Holstein Campus Lübeck
- Lasse M. Giil
- Department of Internal Medicine, Haraldsplass Deaconess Hospital
- Hanna Graßhoff
- Department of Rheumatology, University Medical Center Schleswig-Holstein Campus Lübeck
- Anja Schumann
- Department of Rheumatology, University Medical Center Schleswig-Holstein Campus Lübeck
- Alexander Hackel
- Department of Rheumatology, University Medical Center Schleswig-Holstein Campus Lübeck
- Juliane Junker
- CellTrend Gesellschaft mit beschränkter Haftung (GmbH)
- Carlotta Meyer
- CellTrend Gesellschaft mit beschränkter Haftung (GmbH)
- Hans D. Ochs
- Department of Pediatrics, University of Washington School of Medicine, and Seattle Children’s Research Institute
- Yael Bublil Lavi
- Sackler Faculty of Medicine, Tel-Aviv University
- Carmen Scheibenbogen
- Institute of Medical Immunology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health
- Ralf Dechend
- Experimental and Clinical Research Center, a collaboration of Max Delbruck Center for Molecular Medicine and Charité Universitätsmedizin, and HELIOS Clinic, Department of Cardiology and Nephrology
- Igor Jurisica
- Osteoarthritis Research Program, Division of Orthopedic Surgery, Schroeder Arthritis Institute, UHN; Data Science Discovery Centre, Krembil Research Institute, UHN, Departments of Medical Biophysics and Computer Science, University of Toronto
- Kai Schulze-Forster
- CellTrend Gesellschaft mit beschränkter Haftung (GmbH)
- Jonathan I. Silverberg
- School of Medicine and Health Sciences, George Washington University
- Howard Amital
- Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center
- Jason Zimmerman
- Maimonides Medical Center
- Harry Heidecke
- CellTrend Gesellschaft mit beschränkter Haftung (GmbH)
- Avi Z. Rosenberg
- Department of Pathology, Johns Hopkins University
- Gabriela Riemekasten
- Department of Rheumatology, University Medical Center Schleswig-Holstein Campus Lübeck
- Yehuda Shoenfeld
- Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center
- DOI
- https://doi.org/10.1038/s41467-022-28905-5
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 12
Abstract
COVID-19, similarly to systemic autoimmune diseases, is characterised by the presence of autoantibodies. Authors show here that the abundance and network signature of autoantibodies targeting G protein-coupled receptors and RAS-related proteins are altered in COVID-19 patients, and the level of disruption marks clinical severity.
