Evidence for Transient Receptor Potential (TRP) Channel Contribution to Arthritis Pain and Pathogenesis

Tabitha Galindo; Jose Reyna; Andy Weyer

doi:10.3390/ph11040105

Pharmaceuticals (Oct 2018)

Evidence for Transient Receptor Potential (TRP) Channel Contribution to Arthritis Pain and Pathogenesis

Tabitha Galindo,
Jose Reyna,
Andy Weyer

Affiliations

Tabitha Galindo: School of Physical Therapy and Athletic Training, Pacific University, Hillsboro, OR 97116, USA
Jose Reyna: School of Physical Therapy and Athletic Training, Pacific University, Hillsboro, OR 97116, USA
Andy Weyer: Biological Sciences Department, City College of San Francisco, San Francisco, CA 94112, USA

DOI: https://doi.org/10.3390/ph11040105
Journal volume & issue: Vol. 11, no. 4
p. 105

Abstract

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Based on clinical and preclinical evidence, Transient Receptor Potential (TRP) channels have emerged as potential drug targets for the treatment of osteoarthritis, rheumatoid arthritis, and gout. This review summarizes the relevant data supporting a role for various TRP channels in arthritis pain and pathogenesis, as well as the current state of pharmacological efforts to ameliorate arthritis symptoms in patient populations.

Published in Pharmaceuticals

ISSN: 1424-8247 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine: Pharmacy and materia medica
Website: http://www.mdpi.com/journal/pharmaceuticals/

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