Nature Communications (May 2021)

A human antibody selective for transthyretin amyloid removes cardiac amyloid through phagocytic immune cells

  • Aubin Michalon,
  • Andreas Hagenbuch,
  • Christian Huy,
  • Evita Varela,
  • Benoit Combaluzier,
  • Thibaud Damy,
  • Ole B. Suhr,
  • Maria J. Saraiva,
  • Christoph Hock,
  • Roger M. Nitsch,
  • Jan Grimm

DOI
https://doi.org/10.1038/s41467-021-23274-x
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 12

Abstract

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Analyzing memory B cell repertoires of the healthy elderly enabled Michalon et al. to develop a recombinant human antibody selective for transthyretin amyloid. This antibody removes cardiac amyloid through recruitment of phagocytic immune cells.