Neuroborreliosis and autoimmunity, Guillain Barré Syndrome: two case reports

Abstract

Lyme disease is a multisystemic disease and involvement of the nervous system is called neuroborreliosis. Clinical manifestations of peripheral neuroborreliosis include asymmetric polyradiculopathy, cranial nerve paralysis, multifocal mononeuropathies and sensorymotor polyneuropathies. Guillain-Barré syndrome also known as acute inflammatory demyelinating polyneuropathy is an immune-mediated neuropathy. Only limited number of cases with Lyme disease presented with Guillain-Barré syndrome symptoms are encountered in the literature reviews, which are mostly seen during paediatric age. Herein we will report two patients with Guillain-Barré syndrome who presented with atypical findings and followed up in our clinic. In these cases diagnosis of Lyme disease was confirmed by Western Blot technique which demonstrated the presence of antibodies formed against Borrelia burgdorferi.